1SZM

DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)

Summary for 1SZM

• Entry DOI: 10.2210/pdb1szm/pdb
• Related: 1stc
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE (3 entities in total)
• Functional Keywords: pka, pkc, bisindolyl maleimide 2, ly333531, selectivity, surrogate kinase, amino acid residue exchange, transferase
• Biological source: Bos taurus (cattle)
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 82431.89

Authors

Gassel, M.,Breitenlechner, C.B.,Koenig, N.,Huber, R.,Engh, R.A.,Bossemeyer, D. (deposition date: 2004-04-06, release date: 2004-06-01, Last modification date: 2023-08-23)

• Primary citation: Gassel, M.,Breitenlechner, C.B.,Koenig, N.,Huber, R.,Engh, R.A.,Bossemeyer, D.; The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase a.; J.Biol.Chem., 279:23679-23690, 2004; PubMed: 14996846; DOI: 10.1074/jbc.M314082200

Experimental method

X-RAY DIFFRACTION (2.5 Å)