1SZM
DUAL BINDING MODE OF BISINDOLYLMALEIMIDE 2 TO PROTEIN KINASE A (PKA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | cAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 350 | 40777.4 | 2 | UniProt (P00517) Pfam (PF00069) In PDB | Bos taurus (cattle) | PKA C-alpha, PROTEIN KINASE A |
| 2 | A, B | 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE | non-polymer | 438.5 | 2 | Chemie (BI4) | |||
| 3 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Ala 123 | Val 123 | engineered mutation |
| Sep 139 | Ser 139 | modified residue |
| Met 173 | Leu 173 | engineered mutation |
| Lys 181 | Gln 181 | engineered mutation |
| Tpo 197 | Thr 197 | modified residue |
| Sep 338 | Ser 338 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81554.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 877.0 | |
| All* | Total formula weight | 82431.9 |
