2UZV
PKA structures of indazole-pyridine series of AKT inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (2) | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, | polymer | 20 | 2226.4 | 1 | UniProt (Q3SX13) | BOS TAURUS | PKI-ALPHA |
| 2 | B (A) | CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT | polymer | 336 | 39216.1 | 1 | UniProt (P00517) Pfam (PF00069) | BOS TAURUS (BOVINE) | PROTEIN KINASE A, PKA C-ALPHA |
| 3 | C (A) | (2S)-1-[3-(CYCLOHEXYLMETHOXY)PHENYL]-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE | non-polymer | 470.6 | 1 | Chemie (SS5) |
Sequence modifications
A: 15 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Asp 286 | Asn 286 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41442.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 470.6 | |
| All* | Total formula weight | 41913.1 |
