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1YDR

STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT IN COMPLEX WITH H7 PROTEIN KINASE INHIBITOR 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE

Summary for 1YDR
Entry DOI10.2210/pdb1ydr/pdb
DescriptorC-AMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR PEPTIDE, 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, ... (4 entities in total)
Functional Keywordscomplex (phosphotransferase-inhibitor), transferase, camp, phosphorylation, isoquinoline sulfonamide, serine/threonine-protein kinase, atp-binding, complex (phosphotransferase-inhibitor) complex, complex (phosphotransferase/inhibitor)
Biological sourceBos taurus (cattle)
Cellular locationCytoplasm: P00517
Total number of polymer chains2
Total formula weight43199.14
Authors
Engh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D. (deposition date: 1996-07-24, release date: 1997-04-01, Last modification date: 2011-07-13)
Primary citationEngh, R.A.,Girod, A.,Kinzel, V.,Huber, R.,Bossemeyer, D.
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.
J.Biol.Chem., 271:26157-26164, 1996
Cited by
PubMed: 8824261
DOI: 10.1074/jbc.271.42.26157
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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