1E66

STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-HUPRINE X AT 2.1A RESOLUTION

Summary for 1E66

Entry DOI	10.2210/pdb1e66/pdb
Related	1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1EEA 1EVE 1FSS 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP 3ACE 4ACE
Descriptor	ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CHLORO-9-ETHYL-6,7,8,9,10,11-HEXAHYDRO-7,11-METHANOCYCLOOCTA[B]QUINOLIN-12-AMINE, ... (4 entities in total)
Functional Keywords	cholinesterase, huprine x, alzheimer's disease, chemical hybrid, hydrolase
Biological source	TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
Total number of polymer chains	1
Total formula weight	62066.32
Authors	Dvir, H.,Harel, M.,Silman, I.,Sussman, J.L. (deposition date: 2000-08-08, release date: 2001-08-02, Last modification date: 2023-12-13)
Primary citation	Dvir, H.,Wong, D.M.,Harel, M.,Barril, X.,Orozco, M.,Luque, F.J.,Munoz-Torrero, D.,Camps, P.,Rosenberry, T.L.,Silman, I.,Sussman, J.L. 3D Structure of Torpedo Californica Acetylcholinesterase Complexed with Huprine X at 2. 1 A Resolution: Kinetic and Molecular Dynamic Correlates. Biochemistry, 41:2970-, 2002 Cited by PubMed: 11863435 DOI: 10.1021/BI011652I PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation