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8XPU
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BU of 8xpu by Molmil
Overall structure of the LAT1-4F2hc bound with JPH203
Descriptor: (2~{S})-2-azanyl-3-[4-[(5-azanyl-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-bis(chloranyl)phenyl]propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 5 of Amino acid transporter heavy chain SLC3A2, ...
Authors:Hu, Z, Yan, R.
Deposit date:2024-01-04
Release date:2024-07-17
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203.
Cell Discov, 10, 2024
8WNS
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BU of 8wns by Molmil
Cryo EM map of SLC7A10 in the apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Amino acid transporter heavy chain SLC3A2, Asc-type amino acid transporter 1
Authors:Li, Y.N, Guo, Y.Y, Dai, L, Yan, R.H.
Deposit date:2023-10-06
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Cryo-EM structure of the human Asc-1 transporter complex.
Nat Commun, 15, 2024
8WNY
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BU of 8wny by Molmil
Cryo EM map of SLC7A10-SLC3A2 complex in the D-serine bound state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Amino acid transporter heavy chain SLC3A2, Asc-type amino acid transporter 1, ...
Authors:Li, Y.N, Guo, Y.Y, Dai, L, Yan, R.H.
Deposit date:2023-10-06
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of the human Asc-1 transporter complex.
Nat Commun, 15, 2024
8WNT
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BU of 8wnt by Molmil
Cryo EM map of SLC7A10 with L-Alanine substrate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALANINE, ...
Authors:Li, Y.N, Guo, Y.Y, Dai, L, Yan, R.H.
Deposit date:2023-10-06
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Cryo-EM structure of the human Asc-1 transporter complex.
Nat Commun, 15, 2024
8QEY
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BU of 8qey by Molmil
Structure of human Asc1/CD98hc heteromeric amino acid transporter
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ...
Authors:Martinez-Molledo, M, Rullo-Tubau, J, Errasti-Murugarren, E, Palacin, M, Llorca, O.
Deposit date:2023-09-01
Release date:2024-04-10
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter.
Nat Commun, 15, 2024
8J8L
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BU of 8j8l by Molmil
Overall structure of the LAT1-4F2hc bound with L-dopa
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-DIHYDROXYPHENYLALANINE, 4F2 cell-surface antigen heavy chain, ...
Authors:Yan, R.H, Li, Y.N, Shi, T.H.
Deposit date:2023-05-02
Release date:2024-07-17
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Overall structure of the LAT1-4F2hc bound with L-dopa
To Be Published
8J8M
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BU of 8j8m by Molmil
Overall structure of the LAT1-4F2hc bound with tryptophan
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Large neutral amino acids transporter small subunit 1, ...
Authors:Yan, R.H, Li, Y.N, Shi, T.H.
Deposit date:2023-05-02
Release date:2024-07-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Overall structure of the LAT1-4F2hc bound with tryptophan
To Be Published
8IDA
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BU of 8ida by Molmil
Overall structure of the LAT1-4F2hc bound with tyrosine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Large neutral amino acids transporter small subunit 1, ...
Authors:Yan, R.H, Li, Y.N, Shi, T.H.
Deposit date:2023-02-12
Release date:2024-07-10
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Overall structure of the LAT1-4F2hc bound with tyrosine
To Be Published
8B70
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BU of 8b70 by Molmil
KimA from B. subtilis with nucleotide second-messenger c-di-AMP bound
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, ...
Authors:Vonck, J, Wieferig, J.P.
Deposit date:2022-09-28
Release date:2023-01-18
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cyclic di-AMP traps proton-coupled K + transporters of the KUP family in an inward-occluded conformation.
Nat Commun, 14, 2023
8B71
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BU of 8b71 by Molmil
Upright KimA dimer with bound c-di-AMP from B. subtilis
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Potassium transporter KimA
Authors:Vonck, J, Wieferig, J.P.
Deposit date:2022-09-28
Release date:2023-01-18
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cyclic di-AMP traps proton-coupled K + transporters of the KUP family in an inward-occluded conformation.
Nat Commun, 14, 2023
8A6L
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BU of 8a6l by Molmil
Human 4F2hc-LAT2 heterodimeric amino acid transporter in complex with anticalin D11vs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2hc cell-surface antigen heavy chain, Anticalin D11vs, ...
Authors:Jeckelmann, J.M, Fotiadis, D.
Deposit date:2022-06-18
Release date:2022-11-09
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM.
Sci Rep, 12, 2022
7P9V
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BU of 7p9v by Molmil
Cryo EM structure of System XC-
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter
Authors:Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S.
Deposit date:2021-07-28
Release date:2021-11-17
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
7P9U
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BU of 7p9u by Molmil
Cryo EM structure of System XC- in complex with glutamate
Descriptor: 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter, GLUTAMIC ACID
Authors:Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S.
Deposit date:2021-07-28
Release date:2021-11-17
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
7EPZ
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BU of 7epz by Molmil
Overall structure of Erastin-bound xCT-4F2hc complex
Descriptor: 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATE, 2-[(1S)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, R.H, Li, Y.N, Zhang, Y.Y, Chi, X.M, Zhou, Q.
Deposit date:2021-04-28
Release date:2022-04-06
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis.
Cell Res., 32, 2022
7O82
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BU of 7o82 by Molmil
The L-arginine/agmatine antiporter from E. coli at 1.7 A resolution
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Arginine/agmatine antiporter, DECANE, ...
Authors:Jeckelmann, J.M, Ilgue, H, Kalbermatter, D, Fotiadis, D.
Deposit date:2021-04-14
Release date:2021-09-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding.
Bmc Biol., 19, 2021
7NF8
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BU of 7nf8 by Molmil
Ovine (b0,+AT-rBAT)2 hetero-tetramer, asymmetric unit, rigid-body fitted
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lee, Y, Kuehlbrandt, W.
Deposit date:2021-02-05
Release date:2022-01-19
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Ca 2+ -mediated higher-order assembly of heterodimers in amino acid transport system b 0,+ biogenesis and cystinuria.
Nat Commun, 13, 2022
7NF6
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BU of 7nf6 by Molmil
Ovine b0,+AT-rBAT heterodimer
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lee, Y, Kuehlbrandt, W.
Deposit date:2021-02-05
Release date:2022-01-19
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Ca 2+ -mediated higher-order assembly of heterodimers in amino acid transport system b 0,+ biogenesis and cystinuria.
Nat Commun, 13, 2022
7DSL
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BU of 7dsl by Molmil
Overall structure of the LAT1-4F2hc bound with JX-078
Descriptor: (2~{S})-2-azanyl-7-[(2-phenylphenyl)methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q.
Deposit date:2020-12-31
Release date:2021-03-10
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.
Cell Discov, 7, 2021
7DSQ
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BU of 7dsq by Molmil
Overall structure of the LAT1-4F2hc bound with 3,5-diiodo-L-tyrosine
Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIIODOTYROSINE, ...
Authors:Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q.
Deposit date:2020-12-31
Release date:2021-03-10
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.
Cell Discov, 7, 2021
7DSK
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BU of 7dsk by Molmil
Overall structure of the LAT1-4F2hc bound with JX-075
Descriptor: (2~{S})-2-azanyl-7-(naphthalen-1-ylmethoxy)-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q.
Deposit date:2020-12-31
Release date:2021-03-10
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.
Cell Discov, 7, 2021
7DSN
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BU of 7dsn by Molmil
Overall structure of the LAT1-4F2hc bound with JX-119
Descriptor: (2~{S})-2-azanyl-7-[[2-(1,3-benzoxazol-2-yl)phenyl]methoxy]-3,4-dihydro-1~{H}-naphthalene-2-carboxylic acid, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, R.H, Li, Y.N, Zhang, Y.Y, Zhong, X.Y, Zhou, Q.
Deposit date:2020-12-31
Release date:2021-03-10
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.
Cell Discov, 7, 2021
7B00
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BU of 7b00 by Molmil
Human LAT2-4F2hc complex in the apo-state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Digitonin, Isoform 2 of 4F2 cell-surface antigen heavy chain, ...
Authors:Rodriguez, C.F, Escudero-Bravo, P, Garcia-Martin, C, Boskovic, J, Errasti-Murugarren, E, Palacin, M, Llorca, O.
Deposit date:2020-11-17
Release date:2021-10-27
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.98 Å)
Cite:Structural basis for substrate specificity of heteromeric transporters of neutral amino acids.
Proc Natl Acad Sci U S A, 118, 2021
7CMH
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BU of 7cmh by Molmil
The LAT2-4F2hc complex in complex with tryptophan
Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ...
Authors:Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q.
Deposit date:2020-07-27
Release date:2020-12-23
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
Cell Discov, 6, 2020
7CMI
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BU of 7cmi by Molmil
The LAT2-4F2hc complex in complex with leucine
Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ...
Authors:Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q.
Deposit date:2020-07-27
Release date:2020-12-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
Cell Discov, 6, 2020
7CCS
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BU of 7ccs by Molmil
Consensus mutated xCT-CD98hc complex
Descriptor: 4F2 cell-surface antigen heavy chain, Consensus mutated Anionic Amino Acid Transporter Light Chain, Xc- System
Authors:Oda, K, Lee, Y, Takemoto, M, Yamashita, K, Nishizawa, T, Nureki, O.
Deposit date:2020-06-17
Release date:2020-12-09
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Consensus mutagenesis approach improves the thermal stability of system x c - transporter, xCT, and enables cryo-EM analyses.
Protein Sci., 29, 2020

 

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