8XPU

Overall structure of the LAT1-4F2hc bound with JPH203

Summary for 8XPU

• Entry DOI: 10.2210/pdb8xpu/pdb
• EMDB information: 38561
• Descriptor: Isoform 5 of Amino acid transporter heavy chain SLC3A2, Large neutral amino acids transporter small subunit 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: transporter, slc family, inhibitor, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 129517.65

Authors

Hu, Z.,Yan, R. (deposition date: 2024-01-04, release date: 2024-07-17, Last modification date: 2025-07-23)

• Primary citation: Hu, Z.,Yan, R.; Structural basis for the inhibition mechanism of LAT1-4F2hc complex by JPH203.; Cell Discov, 10:73-73, 2024; PubMed: 38956038; DOI: 10.1038/s41421-024-00697-6

Experimental method

ELECTRON MICROSCOPY (3.3 Å)