5K47
  • Download 5k47
  • View 5k47
Molmil generated image of 5k47
CRYOEM STRUCTURE OF THE HUMAN POLYCYSTIN-2/PKD2 TRP CHANNEL
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Pike, A.C.W., Grieben, M., Shintre, C.A., Tessitore, A., Shrestha, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Burgess-Brown, N.A., Huiskonen, J.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2016-05-20
Release date:2016-08-24
Last modified:2018-10-10
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nat. Struct. Mol. Biol., 24, 2017
5T4D
  • Download 5t4d
  • View 5t4d
Molmil generated image of 5t4d
CRYO-EM STRUCTURE OF POLYCYSTIC KIDNEY DISEASE PROTEIN 2 (PKD2), RESIDUES 198-703
Descriptor:hPKD:198-703, Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Shen, P.S., Yang, X., DeCaen, P.G., Liu, X., Bulkley, D., Clapham, D.E., Cao, E.
Deposit date:2016-08-29
Release date:2016-11-02
Last modified:2017-11-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Cell, 167, 2016
5W3S
  • Download 5w3s
  • View 5w3s
Molmil generated image of 5w3s
CRYO-ELECTRON MICROSCOPY STRUCTURE OF A TRPML3 ION CHANNEL
Descriptor:Mucolipin-3 isoform 1, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ...
Authors:Hirschi, M., Herzik, M.A., Wie, J., Suo, Y., Borschel, W.F., Ren, D., Lander, G.C., Lee, S.Y.
Deposit date:2017-06-08
Release date:2017-10-11
Last modified:2017-11-01
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Nature, 550, 2017
5WJ5
  • Download 5wj5
  • View 5wj5
Molmil generated image of 5wj5
HUMAN TRPML1 CHANNEL STRUCTURE IN CLOSED CONFORMATION
Descriptor:Mucolipin-1
Authors:Schmiege, P., Li, X.
Deposit date:2017-07-21
Release date:2017-10-18
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Human TRPML1 channel structures in open and closed conformations.
Nature, 550, 2017
5WJ9
  • Download 5wj9
  • View 5wj9
Molmil generated image of 5wj9
HUMAN TRPML1 CHANNEL STRUCTURE IN AGONIST-BOUND OPEN CONFORMATION
Descriptor:Mucolipin-1, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione
Authors:Schmiege, P., Li, X.
Deposit date:2017-07-21
Release date:2017-10-18
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Human TRPML1 channel structures in open and closed conformations.
Nature, 550, 2017
5WPQ
  • Download 5wpq
  • View 5wpq
Molmil generated image of 5wpq
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS IN CLOSED I CONFORMATION AT 3.64 ANGSTROM RESOLUTION
Descriptor:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2017-10-25
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5WPT
  • Download 5wpt
  • View 5wpt
Molmil generated image of 5wpt
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS IN CLOSED II CONFORMATION AT 3.75 ANGSTROM RESOLUTION
Descriptor:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2017-10-25
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5WPV
  • Download 5wpv
  • View 5wpv
Molmil generated image of 5wpv
CRYO-EM STRUCTURE OF MAMMALIAN ENDOLYSOSOMAL TRPML1 CHANNEL IN NANODISCS AT 3.59 ANGSTROM RESOLUTION
Descriptor:Mucolipin-1, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Chen, Q., She, J., Guo, J., Bai, X., Jiang, Y.
Deposit date:2017-08-07
Release date:2017-10-18
Last modified:2017-10-25
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
Nature, 550, 2017
5YDZ
  • Download 5ydz
  • View 5ydz
Molmil generated image of 5ydz
STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 1
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE1
  • Download 5ye1
  • View 5ye1
Molmil generated image of 5ye1
STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 2
Descriptor:Mucolipin-1
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE2
  • Download 5ye2
  • View 5ye2
Molmil generated image of 5ye2
MAMMALIAN ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE5
  • Download 5ye5
  • View 5ye5
Molmil generated image of 5ye5
STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO NANODISC
Descriptor:mammalian endo-lysosomal TRPML1 channel, N-ACETYL-D-GLUCOSAMINE
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-11-15
Last modified:2017-11-22
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5Z1W
  • Download 5z1w
  • View 5z1w
Molmil generated image of 5z1w
CRYO-EM STRUCTURE OF POLYCYSTIC KIDNEY DISEASE-LIKE CHANNEL PKD2L1
Descriptor:Polycystic kidney disease 2-like 1 protein, N-ACETYL-D-GLUCOSAMINE
Authors:Zhang, Y.Q.
Deposit date:2017-12-28
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Cryo-EM structure of polycystic kidney disease-like channel PKD2L1
To Be Published
6AYE
  • Download 6aye
  • View 6aye
Molmil generated image of 6aye
HUMAN APO-TRPML3 CHANNEL AT PH 7.4
Descriptor:Mucolipin-3
Authors:Zhou, X., Li, M., Su, D., Jia, Q., Li, H., Li, X., Yang, J.
Deposit date:2017-09-08
Release date:2017-11-08
Last modified:2017-12-20
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
6AYF
  • Download 6ayf
  • View 6ayf
Molmil generated image of 6ayf
TRPML3/ML-SA1 COMPLEX AT PH 7.4
Descriptor:Mucolipin-3, N-ACETYL-D-GLUCOSAMINE
Authors:Zhou, X., Li, M., Su, D., Jia, Q., Li, H., Li, X., Yang, J.
Deposit date:2017-09-08
Release date:2017-11-08
Last modified:2017-12-20
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
6AYG
  • Download 6ayg
  • View 6ayg
Molmil generated image of 6ayg
HUMAN APO-TRPML3 CHANNEL AT PH 4.8
Descriptor:Mucolipin-3
Authors:Zhou, X., Li, M., Su, D., Jia, Q., Li, H., Li, X., Yang, J.
Deposit date:2017-09-08
Release date:2017-11-08
Last modified:2017-12-20
Method:ELECTRON MICROSCOPY (4.65 Å)
Cite:Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Nat. Struct. Mol. Biol., 24, 2017
6D1W
  • Download 6d1w
  • View 6d1w
Molmil generated image of 6d1w
HUMAN PKD2 F604P MUTANT
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Zheng, W., Yang, X., Bulkley, D., Chen, X.Z., Cao, E.
Deposit date:2018-04-12
Release date:2018-06-27
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Nat Commun, 9, 2018
5MKE
  • Download 5mke
  • View 5mke
Molmil generated image of 5mke
CRYOEM STRUCTURE OF POLYCYSTIN-2 IN COMPLEX WITH CATIONS AND LIPIDS
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE, 4-AMINO-5-CYCLOHEXYL-3-HYDROXY-PENTANOIC ACID, ...
Authors:Wilkes, M., Madej, M.G., Ziegler, C.
Deposit date:2016-12-04
Release date:2017-01-18
Last modified:2017-02-15
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
Nat. Struct. Mol. Biol., 24, 2017
5MKF
  • Download 5mkf
  • View 5mkf
Molmil generated image of 5mkf
CRYOEM STRUCTURE OF POLYCYSTIN-2 IN COMPLEX WITH CALCIUM AND LIPIDS
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, ...
Authors:Wilkes, M., Madej, M.G., Ziegler, C.
Deposit date:2016-12-04
Release date:2017-01-18
Last modified:2017-02-15
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.
Nat. Struct. Mol. Biol., 24, 2017
6A70
  • Download 6a70
  • View 6a70
Molmil generated image of 6a70
STRUCTURE OF THE HUMAN PKD1/PKD2 COMPLEX
Descriptor:Polycystin-2, Polycystin-1
Authors:Su, Q., Hu, F., Ge, X., Lei, J., Yu, S., Wang, T., Zhou, Q., Mei, C., Shi, Y.
Deposit date:2018-06-29
Release date:2018-08-15
Last modified:2018-09-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the human PKD1-PKD2 complex.
Science, 361, 2018
6DU8
  • Download 6du8
  • View 6du8
Molmil generated image of 6du8
HUMAN POLYCSYTIN 2-L1
Descriptor:Polycystic kidney disease 2-like 1 protein, N-ACETYL-D-GLUCOSAMINE
Authors:Hulse, R.E., Clapham, D.E., Li, Z., Huang, R.K., Zhang, J.
Deposit date:2018-06-20
Release date:2018-07-25
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Cryo-EM structure of the polycystin 2-l1 ion channel.
Elife, 7, 2018
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2018 Protein Data Bank Japan