6EHG
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COMPLEMENT COMPONENT C3B IN COMPLEX WITH A NANOBODY
Descriptor:Complement C3, hC3Nb1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Jensen, R.K., Andersen, K.R., Gadeberg, T.A.F., Laursen, N.S., Andersen, G.R.
Deposit date:2017-09-13
Release date:2018-02-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293, 2018
5O32
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THE STRUCTURE OF COMPLEMENT COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, Complement factor I, ...
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (4.206209 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5O35
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STRUCTURE OF COMPLEMENT PROTEINS COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, N-ACETYL-D-GLUCOSAMINE
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5M6W
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PROPERDIN IN COMPLEX WITH ALTERNATIVE PATHWAY C3 CONVERTASE
Descriptor:Complement C3, Complement factor B, Staphylococcal complement inhibitor, ...
Authors:Pedersen, D.V., Andersen, G.R.
Deposit date:2016-10-26
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (6 Å)
Cite:Functional and structural insight into properdin control of complement alternative pathway amplification.
EMBO J., 36, 2017
5JPM
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STRUCTURE OF THE COMPLEX OF HUMAN COMPLEMENT C4 WITH MASP-2 REBUILT USING IMDFF
Descriptor:Complement C4-A, Mannan-binding lectin serine protease 2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Croll, T.I., Andersen, G.R.
Deposit date:2016-05-03
Release date:2016-08-10
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
5JPN
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STRUCTURE OF HUMAN COMPLEMENT C4 REBUILT USING IMDFF
Descriptor:Complement C4-A, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Croll, T.I., Andersen, G.R.
Deposit date:2016-05-03
Release date:2016-08-10
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
5JTW
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CRYSTAL STRUCTURE OF COMPLEMENT C4B RE-REFINED USING IMDFF
Descriptor:Complement C4-A, N-ACETYL-D-GLUCOSAMINE
Authors:Croll, T.I., Andersen, G.R.
Deposit date:2016-05-09
Release date:2016-08-10
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
5FO7
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B AT 2.8 ANGSTROM RESOLUTION
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, N-ACETYL-D-GLUCOSAMINE
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO8
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH MCP (CCP1-4)
Descriptor:COMPLEMENT C3, MEMBRANE COFACTOR PROTEIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO9
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH CR1 (CCP15- 17)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT RECEPTOR TYPE 1, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOA
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH DAF (CCP2-4)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOB
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH SMALLPOX INHIBITOR OF COMPLEMENT (SPICE)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5HCC
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND DERMACENTOR ANDERSONI RACI3.
Descriptor:Complement C5, Complement inhibitor, Dermacentor andersoni RaCI3, ...
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCD
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND RHIPICEPHALUS MICROPLUS RACI2
Descriptor:Complement C5, Complement inhibitor, Rhipicephalus microplus RaCI2, ...
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCE
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND RHIPICEPHALUS APPENDICULATUS RACI1
Descriptor:Complement C5, Complement inhibitor, Rhipicephalus appendiculatus RaCI1, ...
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5I5K
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH ECULIZUMAB
Descriptor:Complement C5, Eculizumab heavy chain (variable domain), Eculizumab light chain (variable domain), ...
Authors:Schatz-Jakobsen, J.A., Andersen, G.R.
Deposit date:2016-02-15
Release date:2016-03-16
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway.
J Immunol., 197, 2016
4XAM
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COMPLEMENT COMPONENT C4B
Descriptor:Complement C4-B, Complement C4-A
Authors:Mortensen, S., Kidmose, R.T., Petersen, S.V., Szilagyi, A., Andersen, G.R.
Deposit date:2014-12-15
Release date:2015-05-06
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement.
J Immunol., 194, 2015
4LNV
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CRYSTAL STRUCTURE OF TEP1S
Descriptor:Thioester-containing protein I, N-ACETYL-D-GLUCOSAMINE
Authors:Le, B.V., Williams, M., Logarajah, S., Baxter, R.H.G.
Deposit date:2013-07-12
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles.
Plos Pathog., 8, 2012
4D94
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CRYSTAL STRUCTURE OF TEP1R
Descriptor:Thioester-containing protein 1, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Le, B.V., Williams, M., Logarajah, S., Baxter, R.H.G.
Deposit date:2012-01-11
Release date:2012-10-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Basis for Genetic Resistance of Anopheles gambiae to Plasmodium: Structural Analysis of TEP1 Susceptible and Resistant Alleles.
Plos Pathog., 8, 2012
4FXG
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COMPLEMENT C4 IN COMPLEX WITH MASP-2
Descriptor:Complement C4 beta chain, Complement C4-A alpha chain, Complement C4 gamma chain, ...
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FXK
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HUMAN COMPLEMENT C4
Descriptor:Complement C4 Beta chain, Complement C4-A Alpha chain, Complement C4 gamma chain, ...
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4E0S
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CRYSTAL STRUCTURE OF C5B-6
Descriptor:Complement C5, Complement component C6, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Aleshin, A.E., Stec, B., DiScipio, R., Liddington, R.C.
Deposit date:2012-03-05
Release date:2012-04-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (4.21 Å)
Cite:Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
4A5W
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CRYSTAL STRUCTURE OF C5B6
Descriptor:COMPLEMENT C5, COMPLEMENT COMPONENT C6, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hadders, M.A., Bubeck, D., Forneris, F., Pangburn, M., Llorca, O., Lea, S.M., Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
4ACQ
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ALPHA-2 MACROGLOBULIN
Descriptor:ALPHA-2-MACROGLOBULIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Marrero, A., Duquerroy, S., Trapani, S., Goulas, T., Guevara, T., Andersen, G.R., Navaza, J., Sottrup-Jensen, L., Gomis-Ruth, F.X.
Deposit date:2011-12-17
Release date:2012-02-22
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:The Crystal Structure of Human Alpha(2)-Macroglobulin Reveals a Unique Molecular Cage.
Angew.Chem.Int.Ed.Engl., 51, 2012
3T4A
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STRUCTURE OF A TRUNCATED FORM OF STAPHYLOCOCCAL COMPLEMENT INHIBITOR B BOUND TO HUMAN C3C AT 3.4 ANGSTROM RESOLUTION
Descriptor:Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, ...
Authors:Garcia, B.L., Geisbrecht, B.V., Summers, B.J.
Deposit date:2011-07-25
Release date:2011-11-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.
J.Biol.Chem., 287, 2012
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