8COE

complement C5 in complex with the LCP0195 nanobody

Summary for 8COE

Entry DOI	10.2210/pdb8coe/pdb
Descriptor	Complement C5 beta chain, Complement C5 alpha chain, LCP0195, ... (4 entities in total)
Functional Keywords	innate immunity, complement, terminal pathway, nanobody, antigen-antibody complex, immune system
Biological source	Lama glama More
Total number of polymer chains	3
Total formula weight	200854.66
Authors	Andersen, G.R.,Pedersen, D.V. (deposition date: 2023-02-28, release date: 2024-01-03)
Primary citation	Jindal, S.,Pedersen, D.V.,Gera, N.,Chandler, J.,Patel, R.,Neill, A.,Cone, J.,Zhang, Y.,Yuan, C.X.,Millman, E.E.,Carlin, D.,Puffer, B.,Sheridan, D.,Andersen, G.R.,Tamburini, P. Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration. Mol.Immunol., 165:29-41, 2023 Cited by PubMed: 38142486 DOI: 10.1016/j.molimm.2023.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.2 Å)

Structure validation