8CML

Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2

Summary for 8CML

Entry DOI	10.2210/pdb8cml/pdb
EMDB information	16730
Descriptor	Nanobody UNbC5-2, Complement C5 beta chain, Complement C5 alpha chain, ... (5 entities in total)
Functional Keywords	nanobody, inhibitor, complement, c5, inhibition, convertase, classical pathway, nanobody-antigen complex, alternative pathway, immune system
Biological source	Lama glama More
Total number of polymer chains	4
Total formula weight	219273.93
Authors	De la O Becerra, K.I.,Gros, P. (deposition date: 2023-02-20, release date: 2023-09-27)
Primary citation	Struijf, E.M.,De la O Becerra, K.I.,Ruyken, M.,de Haas, C.J.C.,van Oosterom, F.,Siere, D.Y.,van Keulen, J.E.,Heesterbeek, D.A.C.,Dolk, E.,Heukers, R.,Bardoel, B.W.,Gros, P.,Rooijakkers, S.H.M. Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies. J.Biol.Chem., 299:104956-104956, 2023 Cited by PubMed: 37356719 DOI: 10.1016/j.jbc.2023.104956 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation