7TV9

HUMAN COMPLEMENT COMPONENT C3B IN COMPLEX WITH APL-1030

Summary for 7TV9

Entry DOI	10.2210/pdb7tv9/pdb
Descriptor	Complement C3 beta chain, Complement C3b alpha' chain, APL-1030 Nanofitin, ... (5 entities in total)
Functional Keywords	immune system, complement protein complex
Biological source	synthetic construct More
Total number of polymer chains	3
Total formula weight	183655.56
Authors	Fontano, E.,Nadupalli, A.,Lakshminarasimhan, D.,White, A.,Garlish, J.,Cinier, M.,Chevrel, A.,Perrocheau, A.,Eyerman, D.,Orme, M.,Kitten, O.,Scheibler, L. (deposition date: 2022-02-04, release date: 2022-03-30, Last modification date: 2023-10-18)
Primary citation	Garlich, J.,Cinier, M.,Chevrel, A.,Perrocheau, A.,Eyerman, D.J.,Orme, M.,Kitten, O.,Scheibler, L. Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation. Biomolecules, 12:-, 2022 Cited by PubMed: 35327625 DOI: 10.3390/biom12030432 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation