complement component C3b in complex with a nanobody

Summary for 6EHG

DescriptorComplement C3, hC3Nb1, N-ACETYL-D-GLUCOSAMINE, ... (5 entities in total)
Functional Keywordsprotein complex, inhibitor, complement, complement system, single domain antibody, nanobody, immune system
Biological sourceLama glama (llama)
Total number of polymer chains3
Total molecular weight190572.04
Jensen, R.K.,Andersen, K.R.,Gadeberg, T.A.F.,Laursen, N.S.,Andersen, G.R. (deposition date: 2017-09-13, release date: 2018-02-14, Last modification date: 2019-10-16)
Primary citation
Jensen, R.K.,Pihl, R.,Gadeberg, T.A.F.,Jensen, J.K.,Andersen, K.R.,Thiel, S.,Laursen, N.S.,Andersen, G.R.
A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293:6269-6281, 2018
PubMed: 29497000 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA117.001179
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.26740 0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report