6EHG

complement component C3b in complex with a nanobody

Summary for 6EHG

DescriptorComplement C3, hC3Nb1, N-ACETYL-D-GLUCOSAMINE, ... (5 entities in total)
Functional Keywordsprotein complex, inhibitor, complement, complement system, single domain antibody, nanobody, immune system
Biological sourceLama glama (llama)
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Total number of polymer chains3
Total molecular weight190572.04
Authors
Jensen, R.K.,Andersen, K.R.,Gadeberg, T.A.F.,Laursen, N.S.,Andersen, G.R. (deposition date: 2017-09-13, release date: 2018-02-14, Last modification date: 2019-10-16)
Primary citation
Jensen, R.K.,Pihl, R.,Gadeberg, T.A.F.,Jensen, J.K.,Andersen, K.R.,Thiel, S.,Laursen, N.S.,Andersen, G.R.
A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.
J. Biol. Chem., 293:6269-6281, 2018
PubMed: 29497000 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA117.001179
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.65 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers 0.26740 0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report