6EHG
complement component C3b in complex with a nanobody
Summary for 6EHG
Entry DOI | 10.2210/pdb6ehg/pdb |
Descriptor | Complement C3, hC3Nb1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | protein complex, inhibitor, complement, complement system, single domain antibody, nanobody, immune system |
Biological source | Lama glama (llama) More |
Total number of polymer chains | 3 |
Total formula weight | 190536.01 |
Authors | Jensen, R.K.,Andersen, K.R.,Gadeberg, T.A.F.,Laursen, N.S.,Andersen, G.R. (deposition date: 2017-09-13, release date: 2018-02-14, Last modification date: 2024-01-17) |
Primary citation | Jensen, R.K.,Pihl, R.,Gadeberg, T.A.F.,Jensen, J.K.,Andersen, K.R.,Thiel, S.,Laursen, N.S.,Andersen, G.R. A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. J. Biol. Chem., 293:6269-6281, 2018 Cited by PubMed: 29497000DOI: 10.1074/jbc.RA117.001179 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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