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8T1L
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BU of 8t1l by Molmil
Atomic model of the mammalian mouse Mediator complex with CKM module
Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Zhao, H, Asturias, F.
Deposit date:2023-06-02
Release date:2024-07-03
Method:ELECTRON MICROSCOPY (4.83 Å)
Cite:A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.
To Be Published
8T9D
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BU of 8t9d by Molmil
CryoEM structure of TR-TRAP
Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Zhao, H, Asturias, F.
Deposit date:2023-06-23
Release date:2024-07-03
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (4.66 Å)
Cite:An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.
Mol.Cell, 84, 2024
8T1I
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BU of 8t1i by Molmil
Atomic model of the mammalian Mediator complex with MED26 subunit
Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Zhao, H, Asturias, F.
Deposit date:2023-06-02
Release date:2024-06-12
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (4.68 Å)
Cite:An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II.
Mol.Cell, 84, 2024
8CEO
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BU of 8ceo by Molmil
Yeast RNA polymerase II transcription pre-initiation complex with core Mediator and the +1 nucleosome
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Wang, H, Cramer, P.
Deposit date:2023-02-02
Release date:2023-03-08
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
7UIO
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BU of 7uio by Molmil
Mediator-PIC Early (Composite Model)
Descriptor: ALANINE, ASPARTIC ACID, DNA (37-MER), ...
Authors:Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K.
Deposit date:2022-03-29
Release date:2023-03-01
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
7UIF
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BU of 7uif by Molmil
Mediator-PIC Early (Core B)
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K.
Deposit date:2022-03-29
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
7UIG
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BU of 7uig by Molmil
Mediator-PIC Early (Mediator A)
Descriptor: DNA-directed RNA polymerase II subunit RPB1, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ...
Authors:Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K.
Deposit date:2022-03-29
Release date:2023-02-15
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
7UI9
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BU of 7ui9 by Molmil
Core Mediator-PICearly (Copy A)
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K.
Deposit date:2022-03-28
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
8GXQ
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BU of 8gxq by Molmil
PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y.
Deposit date:2022-09-21
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (5.04 Å)
Cite:Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
8GXS
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BU of 8gxs by Molmil
PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X.
Deposit date:2022-09-21
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (4.16 Å)
Cite:Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
7ENA
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BU of 7ena by Molmil
TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y.
Deposit date:2021-04-16
Release date:2021-05-26
Last modified:2021-06-16
Method:ELECTRON MICROSCOPY (4.07 Å)
Cite:Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
7ENC
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BU of 7enc by Molmil
TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED)
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y.
Deposit date:2021-04-16
Release date:2021-05-26
Last modified:2021-06-16
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
7ENJ
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BU of 7enj by Molmil
Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B)
Descriptor: Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, ...
Authors:Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y.
Deposit date:2021-04-17
Release date:2021-05-19
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
7NVR
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BU of 7nvr by Molmil
Human Mediator with RNA Polymerase II Pre-initiation complex
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Rengachari, S, Schilbach, S, Aibara, S, Cramer, P.
Deposit date:2021-03-15
Release date:2021-05-05
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
7EMF
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BU of 7emf by Molmil
Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation
Descriptor: Isoform 2 of Mediator of RNA polymerase II transcription subunit 16, Isoform 2 of Mediator of RNA polymerase II transcription subunit 8, Mediator of RNA polymerase II transcription subunit 1, ...
Authors:Yin, X, Li, J, Wu, Z, Liu, W, Xu, Y.
Deposit date:2021-04-13
Release date:2021-05-05
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
7LBM
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BU of 7lbm by Molmil
Structure of the human Mediator-bound transcription pre-initiation complex
Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
Authors:Abdella, R, Talyzina, A, He, Y.
Deposit date:2021-01-08
Release date:2021-03-24
Last modified:2021-04-14
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of the human Mediator-bound transcription preinitiation complex.
Science, 372, 2021
6W1S
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BU of 6w1s by Molmil
Atomic model of the mammalian Mediator complex
Descriptor: Mediator of RNA polymerase II transcription subunit 1, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Zhao, H, Young, N, Asturias, F.
Deposit date:2020-03-04
Release date:2021-03-10
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.
Cell, 178, 2019
6XP5
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BU of 6xp5 by Molmil
Head-Middle module of Mediator
Descriptor: HEAT, Med22, Mediator of RNA polymerase II transcription subunit 1, ...
Authors:Zhang, H.Q, Chen, D.C, Kornberg, R.D.
Deposit date:2020-07-08
Release date:2021-03-03
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mediator structure and conformation change.
Mol.Cell, 81, 2021
5OQM
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BU of 5oqm by Molmil
STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR
Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
Authors:Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Urlaub, H, Cramer, P.
Deposit date:2017-08-13
Release date:2018-05-09
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structures of transcription pre-initiation complex with TFIIH and Mediator.
Nature, 551, 2017
5N9J
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BU of 5n9j by Molmil
Core Mediator of transcriptional regulation
Descriptor: Mediator Complex Subunit 9, Mediator of RNA polymerase II transcription subunit 10, Mediator of RNA polymerase II transcription subunit 11, ...
Authors:Nozawa, K, Schneider, T.R, Cramer, P.
Deposit date:2017-02-25
Release date:2017-05-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Core Mediator structure at 3.4 Angstrom extends model of transcription initiation complex.
Nature, 545, 2017
5U0P
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BU of 5u0p by Molmil
Cryo-EM structure of the transcriptional Mediator
Descriptor: Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ...
Authors:Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F.
Deposit date:2016-11-26
Release date:2017-03-08
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mediator structure and rearrangements required for holoenzyme formation.
Nature, 544, 2017
5U0S
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BU of 5u0s by Molmil
Cryo-EM structure of the Mediator-RNAPII complex
Descriptor: Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ...
Authors:Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F.
Deposit date:2016-11-26
Release date:2017-03-08
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Mediator structure and rearrangements required for holoenzyme formation.
Nature, 544, 2017
5SVA
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BU of 5sva by Molmil
Mediator-RNA Polymerase II Pre-Initiation Complex
Descriptor: 108bp HIS4 Promoter Non-template Strand (-92/+16), 108bp HIS4 Promoter Template Strand (+16/-92), DNA repair helicase RAD25, ...
Authors:Robinson, P.J, Bushnell, D.A, Kornberg, R.D.
Deposit date:2016-08-05
Release date:2016-09-28
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (15.3 Å)
Cite:Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex.
Cell, 166, 2016
3FBN
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BU of 3fbn by Molmil
Structure of the Mediator submodule Med7N/31
Descriptor: Mediator of RNA polymerase II transcription subunit 31, Mediator of RNA polymerase II transcription subunit 7
Authors:Koschubs, T, Seizl, M, Lariviere, L, Kurth, F, Baumli, S, Martin, D.E, Cramer, P.
Deposit date:2008-11-19
Release date:2008-12-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.007 Å)
Cite:Identification, structure, and functional requirement of the Mediator submodule Med7N/31
Embo J., 28, 2009
3FBI
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BU of 3fbi by Molmil
Structure of the Mediator submodule Med7N/31
Descriptor: Mediator of RNA polymerase II transcription subunit 31, Mediator of RNA polymerase II transcription subunit 7
Authors:Koschubs, T, Seizl, M, Lariviere, L, Kurth, F, Baumli, S, Martin, D.E, Cramer, P.
Deposit date:2008-11-19
Release date:2008-12-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification, structure, and functional requirement of the Mediator submodule Med7N/31
Embo J., 28, 2009

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