1GW6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
Descriptor:LEUKOTRIENE A-4 HYDROLASE, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, ...
Authors:Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Samuelsson, B., Haeggstrom, J.Z.
Deposit date:2002-03-07
Release date:2003-03-06
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375
Proc.Natl.Acad.Sci.USA, 99, 2002
1H19
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STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Haeggstrom, J.Z.
Deposit date:2002-07-04
Release date:2002-08-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms
J.Biol.Chem., 277, 2002
1HS6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
Descriptor:LEUKOTRIENE A-4 HYDROLASE, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Nordlund, P.N., Haeggstrom, J.Z.
Deposit date:2000-12-24
Release date:2001-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nat.Struct.Biol., 8, 2001
1SQM
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STRUCTURE OF [R563A] LEUKOTRIENE A4 HYDROLASE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Tholander, F.O.T., Rudberg, P.C., Thunnissen, M.M.G.M., Haeggstrom, J.Z.
Deposit date:2004-03-19
Release date:2004-08-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates
J.Biol.Chem., 279, 2004
1Z1W
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CRYSTAL STRUCTURES OF THE TRICORN INTERACTING FACOR F3 FROM THERMOPLASMA ACIDOPHILUM, A ZINC AMINOPEPTIDASE IN THREE DIFFERENT CONFORMATIONS
Descriptor:Tricorn protease interacting factor F3, ZINC ION, SULFATE ION
Authors:Kyrieleis, O.J.P., Goettig, P., Kiefersauer, R., Huber, R., Brandstetter, H.
Deposit date:2005-03-07
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the Tricorn Interacting Factor F3 from Thermoplasma acidophilum, a Zinc Aminopeptidase in Three Different Conformations
J.MOL.BIOL., 394, 2005
1Z5H
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CRYSTAL STRUCTURES OF THE TRICORN INTERACTING FACTOR F3 FROM THERMOPLASMA ACIDOPHILUM
Descriptor:Tricorn protease interacting factor F3, SULFATE ION, ZINC ION
Authors:Kyrieleis, O.J.P., Goettig, P., Kiefersauer, R., Huber, R., Brandstetter, H.
Deposit date:2005-03-18
Release date:2005-06-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of the Tricorn Interacting Factor F3 from Thermoplasma acidophilum, a Zinc Aminopeptidase in Three Different Conformations
J.MOL.BIOL., 349, 2005
2DQ6
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CRYSTAL STRUCTURE OF AMINOPEPTIDASE N FROM ESCHERICHIA COLI
Descriptor:Aminopeptidase N, ZINC ION, SULFATE ION
Authors:Nakajima, Y., Onohara, Y., Ito, K., Yoshimoto, T.
Deposit date:2006-05-22
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition
J.Biol.Chem., 281, 2006
2DQM
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CRYSTAL STRUCTURE OF AMINOPEPTIDASE N COMPLEXED WITH BESTATIN
Descriptor:Aminopeptidase N, ZINC ION, SULFATE ION, ...
Authors:Onohara, Y., Nakajima, Y., Ito, K., Yoshimoto, T.
Deposit date:2006-05-29
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition
J.Biol.Chem., 281, 2006
2GTQ
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CRYSTAL STRUCTURE OF AMINOPEPTIDASE N FROM HUMAN PATHOGEN NEISSERIA MENINGITIDIS
Descriptor:aminopeptidase N, ZINC ION, SULFATE ION
Authors:Nocek, B., Mulligan, R., Bargassa, M., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2006-04-28
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis.
Proteins, 70, 2007
2HPO
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STRUCTURE OF AMINOPEPTIDASE N FROM E. COLI SUGGESTS A COMPARTMENTALIZED, GATED ACTIVE SITE
Descriptor:Aminopeptidase N, ZINC ION, GLYCEROL
Authors:Addlagatta, A., Matthews, B.W., Gay, L.
Deposit date:2006-07-17
Release date:2006-08-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HPT
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CRYSTAL STRUCTURE OF E. COLI PEPN (AMINOPEPTIDASE N)IN COMPLEX WITH BESTATIN
Descriptor:Aminopeptidase N, ZINC ION, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ...
Authors:Addlagatta, A., Matthews, B.W., Gay, L.
Deposit date:2006-07-17
Release date:2006-08-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2R59
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LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH INHIBITOR RB3041
Descriptor:Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Tholander, F., Haeggstrom, J.Z., Thunnissen, M., Muroya, A., Roques, B.P., Fournie-Zaluski, M.C.
Deposit date:2007-09-03
Release date:2008-08-12
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
2VJ8
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COMPLEX OF HUMAN LEUKOTRIENE A4 HYDROLASE WITH A HYDROXAMIC ACID INHIBITOR
Descriptor:LTA4H PROTEIN, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Andersson, B., Wong, C.-H., Samuelsson, B., Haeggstrom, J.Z.
Deposit date:2007-12-07
Release date:2008-01-15
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors
Faseb J., 16, 2002
2XPY
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STRUCTURE OF NATIVE LEUKOTRIENE A4 HYDROLASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, GLYCEROL, ZINC ION, ...
Authors:Helgstrand, C., Hasan, M., Usyal, H., Haeggstrom, J.Z., Thunnissen, M.M.G.M.
Deposit date:2010-08-31
Release date:2010-12-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
2XPZ
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STRUCTURE OF NATIVE YEAST LTA4 HYDROLASE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, (R,R)-2,3-BUTANEDIOL, ZINC ION, ...
Authors:Helgstrand, C., Hasan, M., Usyal, H., Haeggstrom, J.Z., Thunnissen, M.M.G.M.
Deposit date:2010-08-31
Release date:2010-12-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
2XQ0
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STRUCTURE OF YEAST LTA4 HYDROLASE IN COMPLEX WITH BESTATIN
Descriptor:LEUKOTRIENE A-4 HYDROLASE, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ZINC ION, ...
Authors:Helgstrand, C., Hasan, M., Usyal, H., Haeggstrom, J.Z., Thunnissen, M.M.G.M.
Deposit date:2010-08-31
Release date:2010-12-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.955 Å)
Cite:A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
2YD0
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CRYSTAL STRUCTURE OF THE SOLUBLE DOMAIN OF HUMAN ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 ERAP1
Descriptor:ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Vollmar, M., Kochan, G., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Raynor, J., Chaikuad, A., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2011-03-17
Release date:2011-04-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of the Endoplasmic Reticulum Aminopeptidase-1 (Erap1) Reveal the Molecular Basis for N-Terminal Peptide Trimming.
Proc.Natl.Acad.Sci.USA, 108, 2011
2ZXG
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AMINOPEPTIDASE N COMPLEXED WITH THE AMINOPHOSPHINIC INHIBITOR OF PL250, A TRANSITION STATE ANALOGUE
Descriptor:Aminopeptidase N, ZINC ION, N-{(2S)-3-[(1R)-1-aminoethyl](hydroxy)phosphoryl-2-benzylpropanoyl}-L-phenylalanine, ...
Authors:Nakajima, Y., Ito, K., Yoshimoto, T.
Deposit date:2008-12-24
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of aminopeptidase N from Escherichia coli complexed with the transition-state analogue aminophosphinic inhibitor PL250
Acta Crystallogr.,Sect.D, 65, 2009
3B2P
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CRYSTAL STRUCTURE OF E. COLI AMINOPEPTIDASE N IN COMPLEX WITH ARGININE
Descriptor:Aminopeptidase N, ZINC ION, SODIUM ION, ...
Authors:Anthony, A., Leslie, G., Matthews, B.W.
Deposit date:2007-10-18
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the unusual specificity of Escherichia coli aminopeptidase N.
Biochemistry, 47, 2008
3B2X
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CRYSTAL STRUCTURE OF E. COLI AMINOPEPTIDASE N IN COMPLEX WITH LYSINE
Descriptor:Aminopeptidase N, ZINC ION, SODIUM ION, ...
Authors:Addlagatta, A., Gay, L., Matthews, B.W.
Deposit date:2007-10-19
Release date:2008-05-06
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the unusual specificity of Escherichia coli aminopeptidase N.
Biochemistry, 47, 2008
3B34
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CRYSTAL STRUCTURE OF E. COLI AMINOPEPTIDASE N IN COMPLEX WITH PHENYLALANINE
Descriptor:Aminopeptidase N, ZINC ION, SODIUM ION, ...
Authors:Addlagatta, A.
Deposit date:2007-10-19
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for the unusual specificity of Escherichia coli aminopeptidase N.
Biochemistry, 47, 2008
3B37
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CRYSTAL STRUCTURE OF E. COLI AMINOPEPTIDASE N IN COMPLEX WITH TYROSINE
Descriptor:Aminopeptidase N, ZINC ION, SODIUM ION, ...
Authors:Addlagatta, A.
Deposit date:2007-10-19
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the unusual specificity of Escherichia coli aminopeptidase N.
Biochemistry, 47, 2008
3B3B
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CRYSTAL STRUCTURE OF E. COLI AMINOPEPTIDASE N IN COMPLEX WITH TRYPTOPHAN
Descriptor:Aminopeptidase N, ZINC ION, SODIUM ION, ...
Authors:Addlagatta, A.
Deposit date:2007-10-19
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the unusual specificity of Escherichia coli aminopeptidase N.
Biochemistry, 47, 2008
3B7R
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LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH INHIBITOR RB3040
Descriptor:Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Tholander, F., Haeggstrom, J., Thunnissen, M., Muroya, A., Roques, B.-P., Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
3B7S
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[E296Q]LTA4H IN COMPLEX WITH RSR SUBSTRATE
Descriptor:Leukotriene A-4 hydrolase, RSR peptide, ZINC ION, ...
Authors:Tholander, F., Haeggstrom, J., Thunnissen, M., Muroya, A., Roques, B.-P., Fournie-Zaluski, M.-C.
Deposit date:2007-10-31
Release date:2008-09-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.465 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
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