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2WZK
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BU of 2wzk by Molmil
Structure of the Cul5 N-terminal domain at 2.05A resolution.
Descriptor: 1,2-ETHANEDIOL, CULLIN-5
Authors:Muniz, J.R.C, Ayinampudi, V, Zhang, Y, Babon, J.J, Chaikuad, A, Krojer, T, Pike, A.C.W, Vollmar, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bullock, A.N.
Deposit date:2009-11-30
Release date:2009-12-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular Architecture of the Ankyrin Socs Box Family of Cul5-Dependent E3 Ubiquitin Ligases
J.Mol.Biol., 425, 2013
6I2M
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BU of 6i2m by Molmil
Crystal structure of vaccinia virus protein A55 BTB-Back domain in complex with human Cullin-3 N-terminus
Descriptor: Cullin-3, Kelch repeat and BTB domain-containing protein A55
Authors:Gao, G, Graham, S.C.
Deposit date:2018-11-01
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55.
J.Biol.Chem., 294, 2019
4EOZ
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BU of 4eoz by Molmil
Crystal structure of the SPOP BTB domain complexed with the Cul3 N-terminal domain
Descriptor: Cullin-3, Speckle-type POZ protein
Authors:Prive, G.G, Errington, W.J.
Deposit date:2012-04-16
Release date:2012-05-30
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
Structure, 20, 2012
4A64
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BU of 4a64 by Molmil
Crystal structure of the N-terminal domain of human Cul4B at 2.57A resolution
Descriptor: 1,2-ETHANEDIOL, CULLIN-4B
Authors:Vollmar, M, Ayinampudi, V, Cooper, C, Guo, K, Krojer, T, Muniz, J.R.C, von Delft, F, Weigelt, J, Arrowsmith, C.H, Bountra, C, Edwards, A, Bullock, A.
Deposit date:2011-10-31
Release date:2012-02-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal Structure of the N-Terminal Domain of Human Cul4B at 2.57A Resolution
To be Published
3DPL
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BU of 3dpl by Molmil
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation.
Descriptor: Cullin-5, RING-box protein 1, ZINC ION
Authors:Duda, D.M, Schulman, B.A.
Deposit date:2008-07-08
Release date:2008-09-30
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Cell(Cambridge,Mass.), 134, 2008
7Z8R
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BU of 7z8r by Molmil
CAND1-CUL1-RBX1
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
Authors:Baek, K, Schulman, B.A.
Deposit date:2022-03-18
Release date:2023-04-19
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
7Z8V
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BU of 7z8v by Molmil
CAND1-SCF-SKP2 (SKP1deldel) CAND1 engaged SCF rocked
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
Authors:Baek, K, Schulman, B.A.
Deposit date:2022-03-18
Release date:2023-04-19
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
8EI2
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BU of 8ei2 by Molmil
Crystal structure of the N-terminal domain of CUL5 in complex with H314, a Helicon Polypeptide
Descriptor: Cullin-5, H314, N,N'-(1,4-phenylene)diacetamide
Authors:Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
Deposit date:2022-09-14
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
7PLO
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BU of 7plo by Molmil
H. sapiens replisome-CUL2/LRR1 complex
Descriptor: Cell division control protein 45 homolog, Claspin, Cullin-2, ...
Authors:Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M.
Deposit date:2021-09-01
Release date:2021-11-10
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
8I79
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BU of 8i79 by Molmil
Cryo-EM structure of KCTD7 in complex with Cullin3
Descriptor: BTB/POZ domain-containing protein KCTD7, Cullin-3
Authors:Jiang, W, Wang, W, Zheng, S.
Deposit date:2023-01-31
Release date:2023-07-26
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase.
Sci Adv, 9, 2023
4AP2
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BU of 4ap2 by Molmil
Crystal structure of the human KLHL11-Cul3 complex at 2.8A resolution
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CULLIN-3, ...
Authors:Canning, P, Cooper, C.D.O, Krojer, T, Filippakopoulos, P, Ayinampudi, V, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Bullock, A.N, Structural Genomics Consortium (SGC)
Deposit date:2012-03-30
Release date:2012-05-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
7Z8B
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BU of 7z8b by Molmil
Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Descriptor: Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ...
Authors:Hopf, L.V.M, Schulman, B.A.
Deposit date:2022-03-17
Release date:2022-08-24
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.
Nat.Struct.Mol.Biol., 29, 2022
8EI1
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BU of 8ei1 by Molmil
Crystal structure of the N-terminal domain of CUL4B in complex with H316, a Helicon Polypeptide
Descriptor: Cullin-4B, H316, N,N'-(1,4-phenylene)diacetamide
Authors:Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
Deposit date:2022-09-14
Release date:2023-10-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
9GAW
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BU of 9gaw by Molmil
High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D.
Deposit date:2024-07-29
Release date:2024-08-14
Last modified:2024-09-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1
To Be Published
8OR3
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BU of 8or3 by Molmil
CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, DCN1-like protein 1, ...
Authors:Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I.
Deposit date:2023-04-13
Release date:2023-06-28
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.
Mol.Cell, 83, 2023
7Z8T
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BU of 7z8t by Molmil
CAND1-SCF-SKP2 CAND1 engaged SCF rocked
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
Authors:Baek, K, Schulman, B.A.
Deposit date:2022-03-18
Release date:2023-04-19
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
4F52
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BU of 4f52 by Molmil
Structure of a Glomulin-RBX1-CUL1 complex
Descriptor: Cullin-1, E3 ubiquitin-protein ligase RBX1, Glomulin, ...
Authors:Duda, D.M, Olszewski, J.L, Schulman, B.A.
Deposit date:2012-05-11
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface.
Mol.Cell, 47, 2012
7OPD
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BU of 7opd by Molmil
Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 5)
Descriptor: Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ...
Authors:Kokic, G, Cramer, P.
Deposit date:2021-05-31
Release date:2021-10-06
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of human transcription-DNA repair coupling.
Nature, 598, 2021
7OPC
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BU of 7opc by Molmil
Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4)
Descriptor: Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-6, ...
Authors:Kokic, G, Cramer, P.
Deposit date:2021-05-31
Release date:2021-10-13
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of human transcription-DNA repair coupling.
Nature, 598, 2021
3DQV
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BU of 3dqv by Molmil
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
Descriptor: Cullin-5, NEDD8, Rbx1, ...
Authors:Duda, D.M, Borg, L.A, Scott, D.C, Hunt, H.W, Hammel, M, Schulman, B.A.
Deposit date:2008-07-09
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Cell(Cambridge,Mass.), 134, 2008
4JGH
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BU of 4jgh by Molmil
Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5
Descriptor: Cullin-5, Suppressor of cytokine signaling 2, Transcription elongation factor B polypeptide 1, ...
Authors:Kim, Y.K, Kwak, M.J, Ku, B, Suh, H.Y, Joo, K, Lee, J, Jung, J.U, Oh, B.H.
Deposit date:2013-03-01
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes.
Acta Crystallogr.,Sect.D, 69, 2013
1LDJ
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BU of 1ldj by Molmil
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
Descriptor: Cullin homolog 1, ZINC ION, ring-box protein 1
Authors:Zheng, N, Schulman, B.A, Song, L, Miller, J.J, Jeffrey, P.D, Wang, P, Chu, C, Koepp, D.M, Elledge, S.J, Pagano, M, Conaway, R.C, Conaway, J.W, Harper, J.W, Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
7SHK
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BU of 7shk by Molmil
Structure of Xenopus laevis CRL2Lrr1 (State 1)
Descriptor: CULLIN_2 domain-containing protein, Elongin-C, Lrr1, ...
Authors:Zhou, H, Brown, A.
Deposit date:2021-10-09
Release date:2021-12-08
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.
Nucleic Acids Res., 49, 2021
7ZBZ
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BU of 7zbz by Molmil
CAND1 delhairpin-SCF-SKP2 CAND1 partly engaged SCF partly rocked
Descriptor: Cullin-1, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ...
Authors:Baek, K, Schulman, B.A.
Deposit date:2022-03-24
Release date:2023-04-19
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Cell, 186, 2023
2HYE
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BU of 2hye by Molmil
Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex
Descriptor: Cullin-4A, DNA damage-binding protein 1, Nonstructural protein V, ...
Authors:Angers, S, Li, T, Yi, X, MacCoss, M.J, Moon, R.T, Zheng, N.
Deposit date:2006-08-05
Release date:2006-10-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
Nature, 443, 2006

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