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8QH9
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BU of 8qh9 by Molmil
X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a S-29b
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Histone deacetylase 6, ...
Authors:Barinka, C, Motlova, L.
Deposit date:2023-09-07
Release date:2024-08-07
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Biological and structural investigation of tetrahydro-beta-carboline-based selective HDAC6 inhibitors with improved stability.
Eur.J.Med.Chem., 276, 2024
8WZL
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BU of 8wzl by Molmil
Arabidopsis thaliana Histone deacetylase 7 (HDA7)
Descriptor: Histone deacetylase 7, SULFATE ION
Authors:Saharan, K, Vasudevan, D.
Deposit date:2023-11-02
Release date:2024-05-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-function analyses reveal Arabidopsis thaliana HDA7 to be an inactive histone deacetylase.
Curr Res Struct Biol, 7, 2024
8W9F
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BU of 8w9f by Molmil
Cryo-EM structure of the Rpd3S-nucleosome complex from budding yeast in State 3
Descriptor: 3-DNA, 5-DNA, Chromatin modification-related protein EAF3, ...
Authors:Wang, C, Zhan, X.
Deposit date:2023-09-05
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures and dynamics of Rpd3S complex bound to nucleosome.
Sci Adv, 10, 2024
8W9E
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BU of 8w9e by Molmil
Cryo-EM structure of the Rpd3S-nucleosome complex from budding yeast in State 2
Descriptor: 3-DNA, 5-DNA, Chromatin modification-related protein EAF3, ...
Authors:Wang, C, Zhan, X.
Deposit date:2023-09-05
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures and dynamics of Rpd3S complex bound to nucleosome.
Sci Adv, 10, 2024
8W9C
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BU of 8w9c by Molmil
Cryo-EM structure of the Rpd3S complex from budding yeast
Descriptor: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, POTASSIUM ION, ...
Authors:Wang, C, Zhan, X.
Deposit date:2023-09-05
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures and dynamics of Rpd3S complex bound to nucleosome.
Sci Adv, 10, 2024
8W9D
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BU of 8w9d by Molmil
Cryo-EM structure of the Rpd3S-nucleosome complex from budding yeast in State 1
Descriptor: 3-DNA, 5-DNA, Chromatin modification-related protein EAF3, ...
Authors:Wang, C, Zhan, X.
Deposit date:2023-09-05
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures and dynamics of Rpd3S complex bound to nucleosome.
Sci Adv, 10, 2024
8IHN
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BU of 8ihn by Molmil
Cryo-EM structure of the Rpd3S core complex
Descriptor: CALCIUM ION, Chromatin modification-related protein EAF3, Histone H3, ...
Authors:Zhang, Y, Gang, C.
Deposit date:2023-02-23
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme.
Cell Res., 33, 2023
8IHT
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BU of 8iht by Molmil
Rpd3S bound to the nucleosome
Descriptor: CALCIUM ION, Chromatin modification-related protein EAF3, DNA (164-MER), ...
Authors:Zhang, Y, Gang, C.
Deposit date:2023-02-23
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme.
Cell Res., 33, 2023
8TOF
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BU of 8tof by Molmil
Rpd3S bound to an H3K36Cme3 modified nucleosome
Descriptor: Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ...
Authors:Markert, J.W, Vos, S.M, Farnung, L.
Deposit date:2023-08-03
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex.
Nat Commun, 14, 2023
8IFG
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BU of 8ifg by Molmil
Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe
Descriptor: Chromatin modification-related protein eaf3, Cph1, Cph2, ...
Authors:Zhang, H.Q, Wang, X, Wang, Y.N, Liu, S.M, Zhang, Y, Xu, K, Ji, L.T, Kornberg, R.D.
Deposit date:2023-02-17
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Class I histone deacetylase complex: Structure and functional correlates.
Proc Natl Acad Sci U S A, 120, 2023
8G1Z
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BU of 8g1z by Molmil
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz317
Descriptor: 1,2-ETHANEDIOL, 4-(acetamidomethyl)-N-hydroxybenzamide, Hdac6 protein, ...
Authors:Tararina, M.A, Christianson, D.W.
Deposit date:2023-02-03
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.
J.Med.Chem., 66, 2023
8G20
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BU of 8g20 by Molmil
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz327
Descriptor: 1,2-ETHANEDIOL, 4-[(N-butylpentanamido)methyl]-N-hydroxybenzamide, ETHANOL, ...
Authors:Tararina, M.A, Christianson, D.W.
Deposit date:2023-02-03
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.766 Å)
Cite:Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.
J.Med.Chem., 66, 2023
8CJ7
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BU of 8cj7 by Molmil
HDAC6 selective degraded (difluoromethyl)-1,3,4-oxadiazole substrate inhibitor
Descriptor: 6-[(5-pyridin-2-yl-1,2$l^{4},3,4-tetrazacyclopenta-1,3-dien-2-yl)methyl]pyridine-3-carbohydrazide, Histone deacetylase 6, IODIDE ION, ...
Authors:Sandmark, J, Ek, M, Ripa, L.
Deposit date:2023-02-12
Release date:2023-10-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
J.Med.Chem., 66, 2023
8GD4
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BU of 8gd4 by Molmil
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with DMFO Inhibitor 6
Descriptor: 2-(benzylamino)-N'-(difluoroacetyl)pyrimidine-5-carbohydrazide, Hdac6 protein, POTASSIUM ION, ...
Authors:Watson, P.R, Craigin, A.D, Christianson, D.W.
Deposit date:2023-03-03
Release date:2023-10-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 .
J.Med.Chem., 66, 2023
8HY0
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BU of 8hy0 by Molmil
Composite cryo-EM structure of the histone deacetylase complex Rpd3S in complex with nucleosome
Descriptor: Chromatin modification-related protein EAF3, DNA (352-MER), Histone H2A, ...
Authors:Cui, H, Wang, H.
Deposit date:2023-01-05
Release date:2023-09-27
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of histone deacetylase complex Rpd3S bound to nucleosome.
Nat.Struct.Mol.Biol., 30, 2023
8HXX
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BU of 8hxx by Molmil
Cryo-EM structure of the histone deacetylase complex Rpd3S
Descriptor: Chromatin modification-related protein EAF3, Histone H3, Histone deacetylase RPD3, ...
Authors:Cui, H, Wang, H.
Deposit date:2023-01-05
Release date:2023-09-27
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of histone deacetylase complex Rpd3S bound to nucleosome.
Nat.Struct.Mol.Biol., 30, 2023
8HXY
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BU of 8hxy by Molmil
Cryo-EM structure of the histone deacetylase complex Rpd3S in complex with nucleosome
Descriptor: Chromatin modification-related protein EAF3, DNA (352-MER), Histone H2A, ...
Authors:Cui, H, Wang, H.
Deposit date:2023-01-05
Release date:2023-09-27
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of histone deacetylase complex Rpd3S bound to nucleosome.
Nat.Struct.Mol.Biol., 30, 2023
8JHO
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BU of 8jho by Molmil
Cryo-EM structure of the histone deacetylase complex Rpd3S in complex with di-nucleosome
Descriptor: Chromatin modification-related protein EAF3, Di-nucleosome template foward, Di-nucleosome template reverse, ...
Authors:Wang, H.
Deposit date:2023-05-25
Release date:2023-09-27
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structure of histone deacetylase complex Rpd3S bound to nucleosome.
Nat.Struct.Mol.Biol., 30, 2023
8TQ0
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BU of 8tq0 by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with (R)-Lipoic Acid
Descriptor: DIHYDROLIPOIC ACID, Hdac6 protein, POTASSIUM ION, ...
Authors:Watson, P.R, Christianson, D.W.
Deposit date:2023-08-06
Release date:2023-09-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism.
J.Biol.Chem., 299, 2023
8KD5
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BU of 8kd5 by Molmil
Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class2
Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
Authors:Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J.
Deposit date:2023-08-09
Release date:2023-09-13
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KD3
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BU of 8kd3 by Molmil
Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA
Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
Authors:Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
Deposit date:2023-08-09
Release date:2023-09-13
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KD6
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BU of 8kd6 by Molmil
Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class3
Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
Authors:Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
Deposit date:2023-08-09
Release date:2023-09-13
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KD4
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BU of 8kd4 by Molmil
Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class1
Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
Authors:Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
Deposit date:2023-08-09
Release date:2023-09-13
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KC7
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BU of 8kc7 by Molmil
Rpd3S histone deacetylase complex
Descriptor: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ...
Authors:Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
Deposit date:2023-08-06
Release date:2023-09-13
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KD2
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BU of 8kd2 by Molmil
Rpd3S in complex with 187bp nucleosome
Descriptor: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
Authors:Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
Deposit date:2023-08-09
Release date:2023-09-13
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023

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PDB entries from 2024-09-18

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