8CJ7
HDAC6 selective degraded (difluoromethyl)-1,3,4-oxadiazole substrate inhibitor
Summary for 8CJ7
Entry DOI | 10.2210/pdb8cj7/pdb |
Descriptor | Histone deacetylase 6, POTASSIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | inhibitor, small molecule hydrazide, hdac6, oxadiazole, histone, hydrolase |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 3 |
Total formula weight | 122641.26 |
Authors | Sandmark, J.,Ek, M.,Ripa, L. (deposition date: 2023-02-12, release date: 2023-10-18, Last modification date: 2023-11-01) |
Primary citation | Ripa, L.,Sandmark, J.,Hughes, G.,Shamovsky, I.,Gunnarsson, A.,Johansson, J.,Llinas, A.,Collins, M.,Jung, B.,Noven, A.,Pemberton, N.,Mogemark, M.,Xiong, Y.,Li, Q.,Tangefjord, S.,Ek, M.,Astrand, A. Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism. J.Med.Chem., 66:14188-14207, 2023 Cited by PubMed: 37797307DOI: 10.1021/acs.jmedchem.3c01269 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.51 Å) |
Structure validation
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