8CJ7

HDAC6 selective degraded (difluoromethyl)-1,3,4-oxadiazole substrate inhibitor

Summary for 8CJ7

Entry DOI	10.2210/pdb8cj7/pdb
Descriptor	Histone deacetylase 6, POTASSIUM ION, ZINC ION, ... (6 entities in total)
Functional Keywords	inhibitor, small molecule hydrazide, hdac6, oxadiazole, histone, hydrolase
Biological source	Danio rerio (zebrafish)
Total number of polymer chains	3
Total formula weight	122641.26
Authors	Sandmark, J.,Ek, M.,Ripa, L. (deposition date: 2023-02-12, release date: 2023-10-18, Last modification date: 2023-11-01)
Primary citation	Ripa, L.,Sandmark, J.,Hughes, G.,Shamovsky, I.,Gunnarsson, A.,Johansson, J.,Llinas, A.,Collins, M.,Jung, B.,Noven, A.,Pemberton, N.,Mogemark, M.,Xiong, Y.,Li, Q.,Tangefjord, S.,Ek, M.,Astrand, A. Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism. J.Med.Chem., 66:14188-14207, 2023 Cited by PubMed: 37797307 DOI: 10.1021/acs.jmedchem.3c01269 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.51 Å)

Structure validation