8CJ7
HDAC6 selective degraded (difluoromethyl)-1,3,4-oxadiazole substrate inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Histone deacetylase 6 | polymer | 364 | 40285.5 | 3 | UniProt (F8W4B7) Pfam (PF00850) In PDB | Danio rerio (zebrafish) | |
| 2 | A, B, C | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 3 | A, B, C | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | A, B | 6-[(5-pyridin-2-yl-1,2$l^{4},3,4-tetrazacyclopenta-1,3-dien-2-yl)methyl]pyridine-3-carbohydrazide | non-polymer | 296.3 | 2 | Chemie (UTO) | |||
| 5 | A, B, C | IODIDE ION | non-polymer | 126.9 | 6 | Chemie (IOD) | |||
| 6 | water | water | 18.0 | 634 | Chemie (HOH) |
Sequence modifications
A, B, C: 440 - 798 (UniProt: F8W4B7)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 120856.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1784.8 | |
| All* | Total formula weight | 122641.3 |
