8G1Z

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz317

Summary for 8G1Z

Entry DOI	10.2210/pdb8g1z/pdb
Descriptor	Hdac6 protein, 4-(acetamidomethyl)-N-hydroxybenzamide, ZINC ION, ... (6 entities in total)
Functional Keywords	histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase, hydrolase/inhibitor
Biological source	Danio rerio (zebrafish)
Total number of polymer chains	1
Total formula weight	40823.51
Authors	Tararina, M.A.,Christianson, D.W. (deposition date: 2023-02-03, release date: 2023-12-13)
Primary citation	Sinatra, L.,Vogelmann, A.,Friedrich, F.,Tararina, M.A.,Neuwirt, E.,Colcerasa, A.,Konig, P.,Toy, L.,Yesiloglu, T.Z.,Hilscher, S.,Gaitzsch, L.,Papenkordt, N.,Zhai, S.,Zhang, L.,Romier, C.,Einsle, O.,Sippl, W.,Schutkowski, M.,Gross, O.,Bendas, G.,Christianson, D.W.,Hansen, F.K.,Jung, M.,Schiedel, M. Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. J.Med.Chem., 66:14787-14814, 2023 Cited by PubMed: 37902787 DOI: 10.1021/acs.jmedchem.3c01385 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation