8GD4

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with DMFO Inhibitor 6

Summary for 8GD4

Entry DOI	10.2210/pdb8gd4/pdb
Descriptor	Hdac6 protein, 2-(benzylamino)-N'-(difluoroacetyl)pyrimidine-5-carbohydrazide, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase, histone deacetylase, inhibitor, metallohydrolase
Biological source	Danio rerio (zebrafish)
Total number of polymer chains	2
Total formula weight	81500.74
Authors	Watson, P.R.,Craigin, A.D.,Christianson, D.W. (deposition date: 2023-03-03, release date: 2023-10-04, Last modification date: 2023-10-25)
Primary citation	Konig, B.,Watson, P.R.,Ressing, N.,Cragin, A.D.,Schaker-Hubner, L.,Christianson, D.W.,Hansen, F.K. Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 . J.Med.Chem., 66:13821-13837, 2023 Cited by PubMed: 37782298 DOI: 10.1021/acs.jmedchem.3c01345 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation