8U8Y
 
 | | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, interface-centered | | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Calise, S.J, Kollman, J.M. | | Deposit date: | 2023-09-18 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
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8U8O
 | | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, octamer-centered | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, ... | | Authors: | Calise, S.J, Kollman, J.M. | | Deposit date: | 2023-09-18 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
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8U7V
 | | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, interface-centered | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | Authors: | Calise, S.J, Kollman, J.M. | | Deposit date: | 2023-09-15 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
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8U7Q
 | | Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by GTP, ATP, IMP, and NAD+, octamer-centered | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | Authors: | Calise, S.J, Kollman, J.M. | | Deposit date: | 2023-09-15 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
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8U7M
 | | Human retinal variant phosphomimetic IMPDH1(595)-S477D free octamer bound by GTP, ATP, IMP, and NAD+ | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | Authors: | Calise, S.J, Kollman, J.M. | | Deposit date: | 2023-09-15 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.
J.Cell Biol., 223, 2024
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8P4Q
 | | Structure of the IMP dehydrogenase related protein GUAB3 from Synechocystis PCC 6803 | | Descriptor: | IMP dehydrogenase subunit, INOSINIC ACID, XANTHOSINE-5'-MONOPHOSPHATE | | Authors: | Hernandez-Gomez, A, Fernandez-Justel, D, Buey, R.M. | | Deposit date: | 2023-05-23 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution.
Structure, 31, 2023
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8P37
 | | Structure a catalytically inactive mutant of the IMP dehydrogenase related protein GUAB3 from Synechocystis PCC 6803 | | Descriptor: | IMP dehydrogenase subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, XANTHOSINE-5'-MONOPHOSPHATE | | Authors: | Hernandez-Gomez, A, Fernandez-Justel, D, Buey, R.M. | | Deposit date: | 2023-05-17 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.219 Å) | | Cite: | GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution.
Structure, 31, 2023
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8G9B
 | | Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | Authors: | O'Neill, A.G, Kollman, J.M. | | Deposit date: | 2023-02-21 | | Release date: | 2023-04-19 | | Last modified: | 2023-08-09 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
J.Biol.Chem., 299, 2023
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8G8F
 | | Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... | | Authors: | O'Neill, A.G, Kollman, J.M. | | Deposit date: | 2023-02-17 | | Release date: | 2023-04-19 | | Last modified: | 2023-08-09 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
J.Biol.Chem., 299, 2023
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8FUZ
 | | Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; filament assembly interface reconstruction | | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | O'Neill, A.G, Kollman, J.M. | | Deposit date: | 2023-01-18 | | Release date: | 2023-04-19 | | Last modified: | 2023-08-09 | | Method: | ELECTRON MICROSCOPY (2.1 Å) | | Cite: | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
J.Biol.Chem., 299, 2023
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8FOZ
 | | Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; filament assembly interface reconstruction | | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | O'Neill, A.G, Kollman, J.M. | | Deposit date: | 2023-01-03 | | Release date: | 2023-04-19 | | Last modified: | 2023-08-09 | | Method: | ELECTRON MICROSCOPY (2 Å) | | Cite: | Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.
J.Biol.Chem., 299, 2023
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8EBC
 | | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Listeria monocytogenes in the complex with IMP | | Descriptor: | FORMIC ACID, GLYCEROL, INOSINIC ACID, ... | | Authors: | Kim, Y, Maltseva, N, Makowska-Grzyska, M, Osipiuk, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2022-08-31 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Listeria monocytogenes in the complex with IMP
To Be Published
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8CGY
 | | Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; XDS processing | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ... | | Authors: | Boger, J, Schoenherr, R, Lahey-Rudolph, J.M, Harms, M, Kaiser, J, Nachtschatt, S, Wobbe, M, Duden, R, Bourenkov, G, Schneider, T, Redecke, L. | | Deposit date: | 2023-02-06 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst.
Nat Commun, 15, 2024
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8C53
 | | Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; CrystFEL processing | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ... | | Authors: | Lahey-Rudolph, J.M, Schoenherr, R, Boger, J, Harms, M, Kaiser, J, Nachtschatt, S, Wobbe, M, Duden, R, Bourenkov, G, Schneider, T, Redecke, L. | | Deposit date: | 2023-01-06 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst.
Nat Commun, 15, 2024
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8C51
 | | Trypanosoma brucei IMP dehydrogenase (cyto) crystallized in High Five cells revealing native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, ... | | Authors: | Lahey-Rudolph, J.M, Schoenherr, R, Boger, J, Harms, M, Kaiser, J, Nachtschatt, S, Wobbe, M, Duden, R, Koenig, P, Bourenkov, G, Schneider, T, Redecke, L. | | Deposit date: | 2023-01-06 | | Release date: | 2024-01-17 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A streamlined approach to structure elucidation using in cellulo crystallized recombinant proteins, InCellCryst.
Nat Commun, 15, 2024
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7XLO
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7RGQ
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH GTP, ATP, IMP, NAD+; INTERFACE-CENTERED | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | Authors: | Burrell, A.L, Kollman, J.M. | | Deposit date: | 2021-07-15 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGM
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH ATP, IMP, NAD+, OCTAMER-CENTERED | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, ... | | Authors: | Burrell, A.L, Kollman, J.M. | | Deposit date: | 2021-07-15 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGL
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH ATP, IMP, NAD+, INTERFACE-CENTERED | | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Burrell, A.L, Kollman, J.M. | | Deposit date: | 2021-07-15 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGI
 | | HUMAN RETINAL VARIANT IMPDH1(546) TREATED WITH GTP, ATP, IMP, NAD+; INTERFACE-CENTERED | | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Burrell, A.L, Kollman, J.M. | | Deposit date: | 2021-07-15 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RGD
 | | HUMAN RETINAL VARIANT IMPDH1(595) TREATED WITH GTP, ATP, IMP, NAD+, OCTAMER-CENTERED | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | Authors: | Burrell, A.L, Kollman, J.M. | | Deposit date: | 2021-07-15 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RFI
 | | HUMAN RETINAL VARIANT IMPDH1(595) TREATED WITH GTP, ATP, IMP, NAD+, INTERFACE-CENTERED | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1, ... | | Authors: | Burrell, A.L, Kollman, J.M. | | Deposit date: | 2021-07-14 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RFH
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7RFG
 | | HUMAN IMPDH1 TREATED WITH GTP, IMP, AND NAD+ OCTAMER-CENTERED | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... | | Authors: | Burrell, A.L, Kollman, J.M. | | Deposit date: | 2021-07-14 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022
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7RFF
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