8U8Y

Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, interface-centered

Summary for 8U8Y

• Entry DOI: 10.2210/pdb8u8y/pdb
• Related: 8U7M 8U7Q 8U7V 8U8O
• EMDB information: 42029
• Descriptor: Inosine-5'-monophosphate dehydrogenase 1, INOSINIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• Functional Keywords: dehydrogenase, nucleotide synthesis, filament, phosphomimetic, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 476436.30

Authors

Calise, S.J.,Kollman, J.M. (deposition date: 2023-09-18, release date: 2024-01-31, Last modification date: 2024-02-14)

• Primary citation: Calise, S.J.,O'Neill, A.G.,Burrell, A.L.,Dickinson, M.S.,Molfino, J.,Clarke, C.,Quispe, J.,Sokolov, D.,Buey, R.M.,Kollman, J.M.; Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly.; J.Cell Biol., 223:-, 2024; PubMed: 38323936; DOI: 10.1083/jcb.202310139

Experimental method

ELECTRON MICROSCOPY (2.1 Å)