8U8Y
Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, interface-centered
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Inosine-5'-monophosphate dehydrogenase 1 | polymer | 548 | 58542.9 | 8 | UniProt (P20839) Pfam (PF00478) Pfam (PF00571) | Homo sapiens (human) | IMP dehydrogenase 1,IMPD 1,IMPDH 1,IMPDH-I |
| 2 | I, K, M, O, Q... (A, B, C, D, E...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734) | |||
| 3 | J, L, N, P, R... (A, B, C, D, E...) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 509 (UniProt: P20839)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 477 | Ser 477 | engineered mutation |
| Thr 510 | - | variant |
| Phe 511 | - | variant |
| Leu 512 | - | variant |
| Pro 513 | - | variant |
| Phe 514 | - | variant |
| Thr 515 | - | variant |
| Lys 516 | - | variant |
| Ser 517 | - | variant |
| Gly 518 | - | variant |
| Cys 519 | - | variant |
| Thr 520 | - | variant |
| Glu 521 | - | variant |
| Asp 522 | - | variant |
| Ser 523 | - | variant |
| Gly 524 | - | variant |
| Gly 525 | - | variant |
| Gly 526 | - | variant |
| Arg 527 | - | variant |
| Gly 528 | - | variant |
| Gly 529 | - | variant |
| Gly 530 | - | variant |
| Gly 531 | - | variant |
| Asp 532 | - | variant |
| Ala 533 | - | variant |
| Pro 534 | - | variant |
| Gln 535 | - | variant |
| Cys 536 | - | variant |
| Pro 537 | - | variant |
| Leu 538 | - | variant |
| Leu 539 | - | variant |
| Gly 540 | - | variant |
| Thr 541 | - | variant |
| Ala 542 | - | variant |
| Ser 543 | - | variant |
| Leu 544 | - | variant |
| His 545 | - | variant |
| Asn 546 | - | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 468343.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 8093.0 | |
| All* | Total formula weight | 476436.3 |
