8U8Y
Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, interface-centered
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Inosine-5'-monophosphate dehydrogenase 1 | polymer | 548 | 58542.9 | 8 | UniProt (P20839) Pfam (PF00478) Pfam (PF00571) In PDB | Homo sapiens (human) | IMP dehydrogenase 1,IMPD 1,IMPDH 1,IMPDH-I |
2 | A, B, C, D, E... | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) | |||
3 | A, B, C, D, E... | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 509 (UniProt: P20839)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Asp 477 | Ser 477 | engineered mutation |
Thr 510 | - | variant |
Phe 511 | - | variant |
Leu 512 | - | variant |
Pro 513 | - | variant |
Phe 514 | - | variant |
Thr 515 | - | variant |
Lys 516 | - | variant |
Ser 517 | - | variant |
Gly 518 | - | variant |
Cys 519 | - | variant |
Thr 520 | - | variant |
Glu 521 | - | variant |
Asp 522 | - | variant |
Ser 523 | - | variant |
Gly 524 | - | variant |
Gly 525 | - | variant |
Gly 526 | - | variant |
Arg 527 | - | variant |
Gly 528 | - | variant |
Gly 529 | - | variant |
Gly 530 | - | variant |
Gly 531 | - | variant |
Asp 532 | - | variant |
Ala 533 | - | variant |
Pro 534 | - | variant |
Gln 535 | - | variant |
Cys 536 | - | variant |
Pro 537 | - | variant |
Leu 538 | - | variant |
Leu 539 | - | variant |
Gly 540 | - | variant |
Thr 541 | - | variant |
Ala 542 | - | variant |
Ser 543 | - | variant |
Leu 544 | - | variant |
His 545 | - | variant |
Asn 546 | - | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 468343.2 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 8093.0 | |
All* | Total formula weight | 476436.3 |