1FYJ
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SOLUTION STRUCTURE OF MULTI-FUNCTIONAL PEPTIDE MOTIF-1 PRESENT IN HUMAN GLUTAMYL-PROLYL TRNA SYNTHETASE (EPRS).
Descriptor:MULTIFUNCTIONAL AMINOACYL-TRNA SYNTHETASE
Authors:Jeong, E.-J., Hwang, G.-S., Kim, K.H., Kim, M.J., Kim, S., Kim, K.-S.
Deposit date:2000-10-02
Release date:2001-03-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats.
Biochemistry, 39, 2000
1X59
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SOLUTION STRUCTURES OF THE WHEP-TRS DOMAIN OF HUMAN HISTIDYL-TRNA SYNTHETASE
Descriptor:Histidyl-tRNA synthetase
Authors:Nameki, N., Sasagawa, A., Tomizawa, T., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-15
Release date:2005-11-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase
To be Published
2DJV
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SOLUTION STRUCTURES OF THE WHEP-TRS DOMAIN OF HUMAN METHIONYL-TRNA SYNTHETASE
Descriptor:Methionyl-tRNA synthetase
Authors:Sato, M., Sasagawa, A., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2006-04-05
Release date:2006-10-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures of the WHEP-TRS domain of human methionyl-tRNA synthetase
To be Published
1R6T
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CRYSTAL STRUCTURE OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
Descriptor:Tryptophanyl-tRNA synthetase, TRYPTOPHANYL-5'AMP, GLYCEROL
Authors:Yang, X.-L., Otero, F.J., Skene, R.J., McRee, D.E., Ribas de Pouplana, L., Schimmel, P.
Deposit date:2003-10-16
Release date:2004-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Proc.Natl.Acad.Sci.USA, 100, 2003
2AZX
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CHARGED AND UNCHARGED TRNAS ADOPT DISTINCT CONFORMATIONS WHEN COMPLEXED WITH HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
Descriptor:72-MER, Tryptophanyl-tRNA synthetase, SULFATE ION, ...
Authors:Yang, X.L., Otero, F.J., Ewalt, K.L., Liu, J., Swairjo, M.A., Kohrer, C., RajBhandary, U.L., Skene, R.J., McRee, D.E., Schimmel, P.
Deposit date:2005-09-12
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
Embo J., 25, 2006
2PME
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THE APO CRYSTAL STRUCTURE OF THE GLYCYL-TRNA SYNTHETASE
Descriptor:Glycyl-tRNA synthetase
Authors:Xie, W.
Deposit date:2007-04-21
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2PMF
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THE CRYSTAL STRUCTURE OF A HUMAN GLYCYL-TRNA SYNTHETASE MUTANT
Descriptor:Glycyl-tRNA synthetase, CHLORIDE ION, GLYCEROL
Authors:Xie, W.
Deposit date:2007-04-21
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q5H
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CRYSTAL STRUCTURE OF APO-WILDTYPE GLYCYL-TRNA SYNTHETASE
Descriptor:Glycyl-tRNA synthetase
Authors:Cader, M.Z., Ren, J., James, P.A., Bird, L.E., Talbot, K., Stammers, D.K., Oxford Protein Production Facility (OPPF)
Deposit date:2007-06-01
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.
Febs Lett., 581, 2007
2Q5I
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CRYSTAL STRUCTURE OF APO S581L GLYCYL-TRNA SYNTHETASE MUTANT
Descriptor:Glycyl-tRNA synthetase, SULFATE ION
Authors:Cader, M.Z., Ren, J., James, P.A., Bird, L.E., Talbot, K., Stammers, D.K., Oxford Protein Production Facility (OPPF)
Deposit date:2007-06-01
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.
Febs Lett., 581, 2007
2QUH
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CRYSTAL STRUCTURES OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH TRP
Descriptor:Tryptophanyl-tRNA synthetase, TRYPTOPHAN
Authors:Shen, N., Ding, J.P.
Deposit date:2007-08-05
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res., 36, 2008
2QUI
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CRYSTAL STRUCTURES OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH TRYPTOPHANAMIDE AND ATP
Descriptor:Tryptophanyl-tRNA synthetase, MAGNESIUM ION, L-TRYPTOPHANAMIDE, ...
Authors:Shen, N., Ding, J.P.
Deposit date:2007-08-05
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res., 36, 2008
2QUJ
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CRYSTAL STRUCTURES OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH TRPAMP
Descriptor:Tryptophanyl-tRNA synthetase, CHLORIDE ION, TRYPTOPHANYL-5'AMP, ...
Authors:Shen, N., Ding, J.P.
Deposit date:2007-08-05
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res., 36, 2008
2QUK
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CRYSTAL STRUCTURES OF HUMAN TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH ATP(PUTATIVE)
Descriptor:Tryptophanyl-tRNA synthetase
Authors:Shen, N., Ding, J.P.
Deposit date:2007-08-06
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res., 36, 2008
2ZT5
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH ATP)
Descriptor:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT6
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AMPCPP
Descriptor:Glycyl-tRNA synthetase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT7
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLYCINE AND ATP
Descriptor:Glycyl-tRNA synthetase, GLYCINE, ADENOSINE-5'-TRIPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT8
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLY-AMP ANALOG
Descriptor:Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZXF
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH AP4A)
Descriptor:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
Authors:Guo, R.T., Yang, X.L., Schimmel, P.
Deposit date:2008-12-23
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
4G85
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CRYSTAL STRUCTURE OF HUMAN HISRS
Descriptor:Histidine-tRNA ligase, cytoplasmic
Authors:Wei, Z., Wu, J., Zhou, J.J., Yang, X.-L., Zhang, M., Schimmel, P.
Deposit date:2012-07-21
Release date:2012-09-26
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing.
Structure, 20, 2012
4KQE
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THE MUTANT STRUCTURE OF THE HUMAN GLYCYL-TRNA SYNTHETASE E71G
Descriptor:Glycine--tRNA ligase, GLYCEROL
Authors:Qin, X., Hao, Z., Tian, Q., Zhang, Z., Zhou, C., Xie, W.
Deposit date:2013-05-15
Release date:2014-05-21
Last modified:2016-04-13
Method:X-RAY DIFFRACTION (2.739 Å)
Cite:Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis
J.Biol.Chem., 291, 2016
4PHC
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CRYSTAL STRUCTURE OF A HUMAN CYTOSOLIC HISTIDYL-TRNA SYNTHETASE, HISTIDINE-BOUND
Descriptor:Histidine--tRNA ligase, cytoplasmic, HISTIDINE, ...
Authors:Koh, C.Y., Wetzel, A.B., de van der Schueren, W.J., Hol, W.G.J.
Deposit date:2014-05-06
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.
Biochimie, 106, 2014
4X5O
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HUMAN HISTIDINE TRNA SYNTHETASE
Descriptor:Histidine--tRNA ligase, cytoplasmic
Authors:Kim, Y.K., Jeon, Y.H.
Deposit date:2014-12-05
Release date:2015-11-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural characteristics of human histidyl-tRNA synthetase
Biodesign, 2, 2015
5E6M
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CRYSTAL STRUCTURE OF HUMAN WILD TYPE GLYRS BOUND WITH TRNAGLY
Descriptor:Glycine--tRNA ligase, tRNA(Gly), GLYCYL-ADENOSINE-5'-PHOSPHATE, ...
Authors:Xie, W., Qin, X., Deng, X., Chen, L., Liu, Y.
Deposit date:2015-10-10
Release date:2016-07-20
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.927 Å)
Cite:Crystal Structure of the Wild-Type Human GlyRS Bound with tRNA(Gly) in a Productive Conformation
J.Mol.Biol., 428, 2016
5UJJ
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CRYSTAL STRUCTURE OF HUMAN H130R TRYPTOPHANYL-TRNA SYNTHETASE IN COMPLEX WITH TRPAMP
Descriptor:Tryptophan--tRNA ligase, cytoplasmic, TRYPTOPHANYL-5'AMP, ...
Authors:Xu, X., Yang, X.-L.
Deposit date:2017-01-18
Release date:2018-01-17
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function.
RNA Biol, 15, 2018
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