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2ZT6

Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP

Summary for 2ZT6
Entry DOI10.2210/pdb2zt6/pdb
Related2PME 2PMF 2ZT5 2ZT7 2ZT8
DescriptorGlycyl-tRNA synthetase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER (3 entities in total)
Functional Keywordsligase, ap4a, glycine, atp, gly-amp, trna, aminoacyl-trna synthetase, atp-binding, charcot-marie-tooth disease, disease mutation, nucleotide-binding, phosphoprotein, protein biosynthesis
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P41250
Total number of polymer chains1
Total formula weight79210.04
Authors
Guo, R.T.,Yang, X.L.,Schimmel, P. (deposition date: 2008-09-19, release date: 2009-08-25, Last modification date: 2023-11-01)
Primary citationGuo, R.T.,Chong, Y.E.,Guo, M.,Yang, X.L.
Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published,
Experimental method
X-RAY DIFFRACTION (3.08 Å)
Structure validation

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