2ZT8

Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog

Summary for 2ZT8

• Entry DOI: 10.2210/pdb2zt8/pdb
• Related: 2PME 2PMF 2ZT5 2ZT6 2ZT7
• Descriptor: Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate (3 entities in total)
• Functional Keywords: ligase, ap4a, glycine, atp, gly-amp, trna, aminoacyl-trna synthetase, atp-binding, charcot-marie-tooth disease, disease mutation, nucleotide-binding, phosphoprotein, protein biosynthesis
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P41250
• Total number of polymer chains: 1
• Total formula weight: 79108.20

Authors

Guo, R.T.,Yang, X.L.,Schimmel, P. (deposition date: 2008-09-19, release date: 2009-08-25, Last modification date: 2023-11-01)

• Primary citation: Guo, R.T.,Chong, Y.E.,Guo, M.,Yang, X.L.; Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis; To be Published,

Experimental method

X-RAY DIFFRACTION (3.35 Å)