2FYS
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CRYSTAL STRUCTURE OF ERK2 COMPLEX WITH KIM PEPTIDE DERIVED FROM MKP3
Descriptor:Mitogen-activated protein kinase 1, Dual specificity protein phosphatase 6
Authors:Liu, S., Sun, J.P., Zhou, B., Zhang, Z.Y.
Deposit date:2006-02-08
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3
Proc.Natl.Acad.Sci.Usa, 103, 2006
2OJG
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CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
Authors:Xie, X., Jacobs, M.D.
Deposit date:2007-01-12
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors.
J.Med.Chem., 50, 2007
2OJI
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CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH N-BENZYL-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
Authors:Xie, X., Jacobs, M.D.
Deposit date:2007-01-12
Release date:2007-02-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors.
J.Med.Chem., 50, 2007
2OJJ
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CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
Authors:Xie, X., Jacobs, M.D.
Deposit date:2007-01-12
Release date:2007-02-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors.
J.Med.Chem., 50, 2007
2Z7L
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UNPHOSPHORYLATED MITOGEN ACTIVATED PROTEIN KINASE ERK2 IN COMPLEX WITH (4-{[5-CARBAMOYL-4-(3-METHYLANILINO)PYRIMIDIN 2-YL]AMINO}PHENYL)ACETIC ACID
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID, ...
Authors:Katayama, N., Kurihara, H.
Deposit date:2007-08-27
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors
Proteins, 73, 2008
3I5Z
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CRYSTAL STRUCTURE OF ERK2 BOUND TO (S)-N-(2-HYDROXY-1-PHENYLETHYL)-4-(5-METHYL-2-(PHENYLAMINO)PYRIMIDIN-4-YL)-1H-PYRROLE-2-CARBOXAMIDE
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide
Authors:Jacobs, M.D., Xie, X.
Deposit date:2009-07-06
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
J.Med.Chem., 52, 2009
3I60
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CRYSTAL STRUCTURE OF ERK2 BOUND TO (S)-4-(2-(2-CHLOROPHENYLAMINO)-5-METHYLPYRIMIDIN-4-YL)-N-(2-HYDROXY-1-PHENYLETHYL)-1H-PYRROLE-2-CARBOXAMIDE
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 4-{2-[(2-chlorophenyl)amino]-5-methylpyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide
Authors:Jacobs, M.D., Xie, X.
Deposit date:2009-07-06
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.
J.Med.Chem., 52, 2009
3O71
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CRYSTAL STRUCTURE OF ERK2/DCC PEPTIDE COMPLEX
Descriptor:Mitogen-activated protein kinase 1, Peptide of Deleted in Colorectal Cancer, THIOCYANATE ION
Authors:Ma, W.F., Shang, Y., Wei, Z.Y., Wen, W.Y., Wang, W.N., Zhang, M.J.
Deposit date:2010-07-30
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase
Structure, 18, 2010
3QYW
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CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH AN INHIBITOR
Descriptor:Mitogen-activated protein kinase 1, 6-(3-bromophenyl)-7H-purin-2-amine, DIMETHYL SULFOXIDE, ...
Authors:Gelin, M., Pochet, S., Hoh, F., Pirochi, M., Guichou, J.-F., Ferrer, J.-L., Labesse, G.
Deposit date:2011-03-04
Release date:2011-08-24
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.
Acta Crystallogr.,Sect.D, 67, 2011
3QYZ
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CRYSTAL STRUCTURE OF ERK2 IN COMPLEX WITH AN INHIBITOR
Descriptor:Mitogen-activated protein kinase 1, 5'-azido-8-bromo-5'-deoxyadenosine, DIMETHYL SULFOXIDE, ...
Authors:Gelin, M., Pochet, S., Hoh, F., Pirochi, M., Guichou, J.-F., Ferrer, J.-L., Labesse, G.
Deposit date:2011-03-04
Release date:2011-08-24
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:In-plate protein crystallization, in situ ligand soaking and X-ray diffraction.
Acta Crystallogr.,Sect.D, 67, 2011
3R63
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STRUCTURE OF ERK2 (SPE) MUTANT (S246E)
Descriptor:Mitogen-activated protein kinase 1
Authors:Livnah, O., Karamansha, Y.
Deposit date:2011-03-21
Release date:2011-08-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation.
Mol.Cell.Biol., 31, 2011
3SA0
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COMPLEX OF ERK2 WITH NORATHYRIOL
Descriptor:Mitogen-activated protein kinase 1, norathyriol, SULFATE ION
Authors:Kurinov, I., Malakhova, M.
Deposit date:2011-06-02
Release date:2011-12-14
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.5947 Å)
Cite:Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases.
Cancer Res., 72, 2012
3TEI
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CRYSTAL STRUCTURE OF HUMAN ERK2 COMPLEXED WITH A MAPK DOCKING PEPTIDE
Descriptor:Mitogen-activated protein kinase 1, Ribosomal protein S6 kinase alpha-1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Gogl, G., Remenyi, A.
Deposit date:2011-08-15
Release date:2012-08-15
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.404 Å)
Cite:Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.
Sci.Signal., 5, 2012
3W55
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THE STRUCTURE OF ERK2 IN COMPLEX WITH FR148083
Descriptor:Mitogen-activated protein kinase 1, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
Authors:Ohori, M., Kinoshita, T.
Deposit date:2013-01-21
Release date:2013-02-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Role of a cysteine residue in the active site of ERK and the MAPKK family
Biochem.Biophys.Res.Commun., 353, 2007
4FMQ
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CRYSTAL STRUCTURE OF HUMAN ERK2 COMPLEXED WITH A MAPK DOCKING PEPTIDE
Descriptor:Mitogen-activated protein kinase 1, MAPK DOCKING PEPTIDE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Gogl, G., Toeroe, I., Remenyi, A.
Deposit date:2012-06-18
Release date:2012-10-31
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.
Sci.Signal., 5, 2012
4FUX
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH E75
Descriptor:Mitogen-activated protein kinase 1, trans-4-{[4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)pyrimidin-2-yl]amino}cyclohexanol, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-28
Release date:2012-08-22
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the ERK2 complexed with E75
TO BE PUBLISHED
4FUY
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK2
Descriptor:Mitogen-activated protein kinase 1, {4-[4-(3,5-dichlorophenyl)-1H-pyrazol-5-yl]-1H-pyrrol-2-yl}(morpholin-4-yl)methanone, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-28
Release date:2012-08-22
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the ERK2 complexed with EK2
TO BE PUBLISHED
4FV0
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK3
Descriptor:Mitogen-activated protein kinase 1, N-cyclohexyl-4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridin-2-amine, 1,2-ETHANEDIOL, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-28
Release date:2012-08-22
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the ERK2 complexed with EK3
TO BE PUBLISHED
4FV1
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK4
Descriptor:Mitogen-activated protein kinase 1, N-[(1S)-2-hydroxy-1-phenylethyl]-4-{4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}-1H-pyrrole-2-carboxamide, GLYCEROL, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-28
Release date:2012-08-22
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal Structure of the ERK2 complexed with EK4
TO BE PUBLISHED
4FV2
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK5
Descriptor:Mitogen-activated protein kinase 1, 4-[4-(3-chlorophenyl)-1H-pyrazol-5-yl]-N-(2,3-dihydro-1-benzofuran-5-ylmethyl)-1H-pyrrole-2-carboxamide, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-29
Release date:2012-08-29
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the ERK2 complexed with EK5
TO BE PUBLISHED
4FV3
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK6
Descriptor:Mitogen-activated protein kinase 1, ethyl N-{2-chloro-4-[5-(5-{[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]carbamoyl}-1H-pyrrol-3-yl)-1H-pyrazol-4-yl]benzyl}glycinate, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-29
Release date:2012-08-29
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the ERK2 complexed with EK6
TO BE PUBLISHED
4FV4
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK7
Descriptor:Mitogen-activated protein kinase 1, 9-(dimethylamino)-2-[(3-hydroxyphenyl)amino]-5,6-dihydrothieno[3,4-h]quinazoline-7-carbonitrile, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-29
Release date:2012-08-29
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the ERK2 complexed with EK7
TO BE PUBLISHED
4FV5
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK9
Descriptor:Mitogen-activated protein kinase 1, N-[(1S)-2-hydroxy-1-phenylethyl]-4-(5-methyl-2-phenylpyrimidin-4-yl)-1H-pyrrole-2-carboxamide, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-29
Release date:2012-08-29
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the ERK2 complexed with EK9
TO BE PUBLISHED
4FV6
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH E57
Descriptor:Mitogen-activated protein kinase 1, N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-4-(2-{[(2S)-1-hydroxybutan-2-yl]amino}-5-methylpyrimidin-4-yl)-1H-pyrrole-2-carboxamide, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-29
Release date:2012-08-29
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the ERK2 complexed with E57
TO BE PUBLISHED
4FV7
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CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH E94
Descriptor:Mitogen-activated protein kinase 1, 4-(3-chlorophenyl)-5-{2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}-2-{[2-(piperidin-1-yl)ethyl]amino}thiophene-3-carbonitrile, SULFATE ION, ...
Authors:Kang, Y.N., Stuckey, J.A., Xie, X.
Deposit date:2012-06-29
Release date:2012-08-29
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the ERK2 complexed with E94
TO BE PUBLISHED