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5VMN
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BU of 5vmn by Molmil
Crystal structure of grouper iridovirus GIV66
Descriptor: 1,2-ETHANEDIOL, Bak protein, NITRATE ION
Authors:Banjara, S, Kvansakul, M.
Deposit date:2017-04-27
Release date:2018-03-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.
J. Biol. Chem., 293, 2018
5VKC
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BU of 5vkc by Molmil
Crystal structure of MCL-1 in complex with a BIM competitive inhibitor
Descriptor: 7-(3-{[4-(4-acetylpiperazin-1-yl)phenoxy]methyl}-1,5-dimethyl-1H-pyrazol-4-yl)-3-{3-[(naphthalen-1-yl)oxy]propyl}-1-[(pyridin-3-yl)methyl]-1H-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION
Authors:Judge, R.A, Souers, A.J.
Deposit date:2017-04-21
Release date:2017-05-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
J. Med. Chem., 58, 2015
5W60
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BU of 5w60 by Molmil
Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol
Descriptor: Apoptosis regulator BAX, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W61
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BU of 5w61 by Molmil
Crystal structure of BAXP168G monomer co-crystallized with glycerol
Descriptor: Apoptosis regulator BAX
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W63
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Crystal structure of channel catfish BAX
Descriptor: 1,2-ETHANEDIOL, Apoptosis regulator bax, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.436 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5W89
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BU of 5w89 by Molmil
Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18
Authors:Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E.
Deposit date:2017-06-21
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5W8F
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BU of 5w8f by Molmil
Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14
Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-14
Authors:Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E.
Deposit date:2017-06-21
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5TZP
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BU of 5tzp by Molmil
Crystal structure of FPV039:Bik BH3 complex
Descriptor: 1,2-ETHANEDIOL, Bcl-2-like protein FPV039, Bik, ...
Authors:Anasir, M.I, Kvansakul, M.
Deposit date:2016-11-22
Release date:2017-05-03
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039.
J. Biol. Chem., 292, 2017
5WHH
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BU of 5whh by Molmil
Crystal Structure of Bcl-2-related protein A1 in complex with stapled peptide (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2)
Descriptor: (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2), Bcl-2-related protein A1, CHLORIDE ION
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2017-07-17
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Structure, 26, 2018
5UUL
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BU of 5uul by Molmil
Human Bfl-1 in complex with PUMA BH3
Descriptor: Bcl-2-binding component 3, Bcl-2-related protein A1, SULFATE ION
Authors:Jenson, J.M, Grant, R.A, Keating, A.E.
Deposit date:2017-02-17
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Elife, 6, 2017
5W62
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BU of 5w62 by Molmil
Crystal structure of mouse BAX monomer
Descriptor: Apoptosis regulator BAX, SULFATE ION
Authors:Robin, A.Y, Colman, P.M, Czabotar, P.E, Luo, C.S.
Deposit date:2017-06-16
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Ensemble Properties of Bax Determine Its Function.
Structure, 26, 2018
5WDD
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BU of 5wdd by Molmil
Crystal structure of chicken BOK
Descriptor: 1,2-ETHANEDIOL, Bcl-2-related ovarian killer protein
Authors:Cowan, A.D, Colman, P.M, Czabotar, P.E.
Deposit date:2017-07-04
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.
Cell, 173, 2018
8QSO
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BU of 8qso by Molmil
Crystal structure of human Mcl-1 in complex with compound 1
Descriptor: (13S,16R,19S)-16-benzyl-43-ethoxy-N-methyl-7,11,14,17-tetraoxo-13-phenyl-5-oxa-2,8,12,15,18-pentaaza-1(1,4),4(1,2)-dibenzena-9(1,4)-cyclohexanacycloicosaphane-19-carboxamide, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Hekking, K.F.W, Gremmen, S, Maroto, S, Keefe, A.D, Zhang, Y.
Deposit date:2023-10-10
Release date:2024-02-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.106 Å)
Cite:Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
J.Med.Chem., 67, 2024
9BCG
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BU of 9bcg by Molmil
Myeloid cell leukemia-1 (Mcl-1) complexed with compound
Descriptor: 7-[(4R,5S,6P)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-4,5-dimethoxy-1-methyl-1H-indole-2-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Zhao, B, Fesik, S.W.
Deposit date:2024-04-09
Release date:2024-08-07
Last modified:2024-09-11
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors.
J.Med.Chem., 67, 2024
4LXD
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BU of 4lxd by Molmil
Bcl_2-Navitoclax Analog (without Thiophenyl) Complex
Descriptor: 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide, Apoptosis regulator Bcl-2
Authors:Park, C.H.
Deposit date:2013-07-29
Release date:2013-08-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
NAT.MED. (N.Y.), 19, 2013
2A5Y
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BU of 2a5y by Molmil
Structure of a CED-4/CED-9 complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Apoptosis regulator ced-9, MAGNESIUM ION, ...
Authors:Yan, N, Liu, Q, Hao, Q, Gu, L, Shi, Y.
Deposit date:2005-07-01
Release date:2005-10-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.
Nature, 437, 2005
7CA4
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BU of 7ca4 by Molmil
The Crystal Structure of human Bcl-2-like protein 1 from Biortus
Descriptor: Bcl-2-like protein 1, SULFATE ION
Authors:Wang, F, Lv, Z, Lin, D, Huang, Y.
Deposit date:2020-06-08
Release date:2020-07-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Crystal Structure of human Bcl-2-like protein 1 from Biortus.
To Be Published
4CIM
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BU of 4cim by Molmil
Complex of a Bcl-w BH3 mutant with a BH3 domain
Descriptor: 1,2-ETHANEDIOL, BCL-2-LIKE PROTEIN 2
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
4EHR
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BU of 4ehr by Molmil
Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide
Descriptor: 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, Bcl-2-like protein 1, IMIDAZOLE
Authors:Schroeder, G.M, Wei, D, Banfi, P, Cai, Z, Lippy, J, Menichincheri, M, Modugno, M, Naglich, J, Penhallow, B, Perez, H.L, Sack, J, Schmidt, R.J, Tebben, A, Yan, C, Zhang, L, Galvani, A, Lombardo, L.J, Borzilleri, R.M.
Deposit date:2012-04-03
Release date:2012-06-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Bioorg.Med.Chem.Lett., 22, 2012
4CIN
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BU of 4cin by Molmil
Complex of Bcl-xL with its BH3 domain
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BCL-2-LIKE PROTEIN 1, ...
Authors:Colman, P.M, Lee, E.F, Fairlie, W.D.
Deposit date:2013-12-12
Release date:2014-11-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:The Functional Differences of Pro-Survival and Pro-Apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (Bh3) Domains
J.Biol.Chem., 289, 2014
1AF3
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BU of 1af3 by Molmil
RAT BCL-XL AN APOPTOSIS INHIBITORY PROTEIN
Descriptor: APOPTOSIS REGULATOR BCL-X
Authors:Aritomi, M, Kunishima, N, Inohara, N, Ishibashi, Y, Ohta, S, Morikawa, K.
Deposit date:1997-03-21
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family.
J.Biol.Chem., 272, 1997
2BZW
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BU of 2bzw by Molmil
The crystal structure of BCL-XL in complex with full-length BAD
Descriptor: APOPTOSIS REGULATOR BCL-X, BCL2-ANTAGONIST OF CELL DEATH
Authors:Lee, K.-H, Han, W.-D, Kim, K.-J, Oh, B.-H.
Deposit date:2005-08-24
Release date:2007-02-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral Bcl-2 of Murine Gamma-Herpesvirus 68.
Plos Pathog., 4, 2008
3MQP
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BU of 3mqp by Molmil
Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide, Northeast Structural Genomics Consortium Target HR2930
Descriptor: Bcl-2-related protein A1, Phorbol-12-myristate-13-acetate-induced protein 1
Authors:Guan, R, Xiao, R, Zhao, L, Acton, T.B, Gelinas, C, Montelione, G.T, Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-04-28
Release date:2010-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Crystal Structure of human BFL-1 in complex with NOXA BH3 peptide
To be Published
1BXL
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BU of 1bxl by Molmil
STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: BAK PEPTIDE, BCL-XL
Authors:Sattler, M, Liang, H, Nettesheim, D, Meadows, R.P, Harlan, J.E, Eberstadt, M, Yoon, H, Shuker, S.B, Chang, B.S, Minn, A.J, Thompson, C.B, Fesik, S.W.
Deposit date:1996-10-16
Release date:1997-10-29
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science, 275, 1997
2B48
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BU of 2b48 by Molmil
Bcl-XL 3D Domain Swapped Dimer
Descriptor: Apoptosis regulator Bcl-X
Authors:O'Neill, J.W, Manion, M.K, Maguire, B, Hockenbery, D.M.
Deposit date:2005-09-22
Release date:2006-02-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:BCL-X(L) Dimerization by Three-dimensional Domain Swapping.
J.Mol.Biol., 356, 2006

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