PDB: 1415 resultsInfo pagesStatus searchChemie searchBIRD

---

8TE6	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain Descriptor: V-set and immunoglobulin domain-containing protein 4 Authors: Abram, T.G, Geisbrecht, B.V. Deposit date: 2023-07-05 Release date: 2023-07-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.251 Å) Cite: New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8TE5	Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain Descriptor: V-set and immunoglobulin domain-containing protein 4 Authors: Abram, T.G, Geisbrecht, B.V. Deposit date: 2023-07-05 Release date: 2023-07-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.502 Å) Cite: New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants. Immunohorizons, 7, 2023
8RPB	Structure of S79 Fab in complex with IgV domain of human PD-L1 Descriptor: CHLORIDE ION, GLYCEROL, Programmed cell death 1 ligand 1, ... Authors: Svensson, A, Kelpsas, V, Laursen, M, Rose, N. Deposit date: 2024-01-15 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (2.794 Å) Cite: Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1. Mabs, 16, 2024
8JBA	Discovery and Crystallography Study of Novel Oxadiazole Analogs as Small Molecule PD-1/PD-L1 inhibitors Descriptor: (2~{S})-2-[[3-[[5-[(2-methyl-3-phenyl-phenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]methylamino]-3-oxidanyl-propanoic acid, Programmed cell death 1 ligand 1 Authors: Cheng, Y, Xiao, Y.B. Deposit date: 2023-05-08 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J.Med.Chem., 66, 2023
8U0Y	Bacterial protein cpx Descriptor: Fluorescent protein, PHYCOUROBILIN, Receptor A, ... Authors: Gully, B.S, Rossjohn, J. Deposit date: 2023-08-29 Release date: 2024-09-04 Method: X-RAY DIFFRACTION (3 Å) Cite: Bacterial protein cpx To Be Published
8U31	Crystal structure of PD-1 in complex with a Fab Descriptor: Fab heavy chain, Fab light chain, GLYCEROL, ... Authors: Sun, D, Masureel, M. Deposit date: 2023-09-07 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
8U32	Crystal structure of PD-1 in complex with a Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ... Authors: Sun, D, Masureel, M. Deposit date: 2023-09-07 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. Mabs, 16, 2024
8JEL	Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Descriptor: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain Authors: Sun, J, Zhang, X.X, Song, J. Deposit date: 2023-05-16 Release date: 2024-02-28 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8JEO	Crystal structure of TIGIT in complexed with Tiragolumab Descriptor: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain Authors: Sun, J, Zhang, X.X, Song, J. Deposit date: 2023-05-16 Release date: 2024-02-28 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
8JEN	Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Descriptor: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain Authors: Sun, J, Zhang, X.X, Song, J. Deposit date: 2023-05-16 Release date: 2024-02-28 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32, 2024
5GGS	PD-1 in complex with pembrolizumab Fab Descriptor: Programmed cell death protein 1, heavy chain, light chain Authors: Heo, Y.S. Deposit date: 2016-06-16 Release date: 2016-11-09 Last modified: 2016-11-16 Method: X-RAY DIFFRACTION (1.997 Å) Cite: Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5GGV	CTLA-4 in complex with tremelimumab Fab Descriptor: Cytotoxic T-lymphocyte protein 4, heavy chain, light chain Authors: Heo, Y.S. Deposit date: 2016-06-16 Release date: 2016-11-09 Last modified: 2016-11-16 Method: X-RAY DIFFRACTION (1.998 Å) Cite: Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5GGT	PD-L1 in complex with BMS-936559 Fab Descriptor: IGK@ protein, IgG H chain, Programmed cell death 1 ligand 1 Authors: Heo, Y.S. Deposit date: 2016-06-16 Release date: 2016-11-09 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5GGR	PD-1 in complex with nivolumab Fab Descriptor: Programmed cell death protein 1, heavy chain, light chain Authors: Heo, Y.S. Deposit date: 2016-06-16 Release date: 2016-11-09 Last modified: 2016-11-16 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7, 2016
5IMO	Nanobody targeting mouse Vsig4 in Spacegroup P3221 Descriptor: Nanobody, Protein Vsig4 Authors: Wen, Y, Zheng, F. Deposit date: 2016-03-06 Release date: 2017-01-11 Last modified: 2017-07-05 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity Immunobiology, 222, 2017
5HDO	Crystal structure of a nanobody raised against urokinase-type plasminogen activator Descriptor: Anti-HCV NS3/4A serine protease immoglobulin heavy chain, CHLORIDE ION, SULFATE ION Authors: Kromann-Hansen, T. Deposit date: 2016-01-05 Release date: 2016-06-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.16 Å) Cite: A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior. J.Biol.Chem., 291, 2016
5IR3	Crystal structure of the recombinant highest fibrillogenic natural mutant (obtained from patient AR) derived from lambda 6 light chain variable domain Descriptor: ACETATE ION, Ig lambda chain V-VI region AR Authors: Hernandez-Santoyo, A, Rodriguez-Romero, A. Deposit date: 2016-03-11 Release date: 2017-06-14 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Stabilizing an amyloidogenic lambda 6 light chain variable domain. FEBS J., 284, 2017
5IMM	Nanobody targeting mouse Vsig4 in Spacegroup P212121 Descriptor: Nanobody, Protein Vsig4 Authors: Wen, Y, Zheng, F. Deposit date: 2016-03-06 Release date: 2017-01-11 Last modified: 2017-07-05 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity Immunobiology, 222, 2017
1VFA	BOUND WATER MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN-ANTIBODY ASSOCIATION Descriptor: IGG1-KAPPA D1.3 FV (HEAVY CHAIN), IGG1-KAPPA D1.3 FV (LIGHT CHAIN) Authors: Bhat, T.N, Poljak, R.J. Deposit date: 1993-12-03 Release date: 1994-05-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Bound water molecules and conformational stabilization help mediate an antigen-antibody association. Proc.Natl.Acad.Sci.USA, 91, 1994
1WZ1	Crystal structure of the Fv fragment complexed with dansyl-lysine Descriptor: Ig heavy chain, Ig light chain, N~6~-{[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}-L-LYSINE Authors: Nakasako, M, Oka, T, Mashumo, M, Takahashi, H, Shimada, I, Yamaguchi, Y, Kato, K, Arata, Y. Deposit date: 2005-02-21 Release date: 2006-01-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Conformational dynamics of complementarity-determining region H3 of an anti-dansyl Fv fragment in the presence of its hapten J.Mol.Biol., 351, 2005
1WTL	COMPARISON OF CRYSTAL STRUCTURES OF TWO HOMOLOGOUS PROTEINS: STRUCTURAL ORIGIN OF ALTERED DOMAIN INTERACTIONS IN IMMUNOGLOBULIN LIGHT CHAIN DIMERS Descriptor: BENCE-JONES PROTEIN MCG (LIGHT CHAIN) Authors: Huang, D.B, Chang, C.H, Schiffer, M. Deposit date: 1994-06-08 Release date: 1994-11-01 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Comparison of crystal structures of two homologous proteins: structural origin of altered domain interactions in immunoglobulin light-chain dimers. Biochemistry, 33, 1994
1VES	Structure of New Antigen Receptor variable domain from sharks Descriptor: New Antigen Receptor variable domain Authors: Streltsov, V.A. Deposit date: 2004-04-05 Release date: 2004-08-24 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor Proc.Natl.Acad.Sci.USA, 101, 2004
1VER	Structure of New Antigen Receptor variable domain from sharks Descriptor: New Antigen Receptor variable domain Authors: Streltsov, V.A. Deposit date: 2004-04-05 Release date: 2004-08-24 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor Proc.Natl.Acad.Sci.USA, 101, 2004
1Z9M	Crystal Structure of Nectin-like molecule-1 protein Domain 1 Descriptor: GAPA225 Authors: Dong, X, Xu, F, Gong, Y, Gao, J, Lin, P, Chen, T, Peng, Y, Qiang, B, Yuan, J, Peng, X, Rao, Z. Deposit date: 2005-04-03 Release date: 2006-02-07 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structure of the V Domain of Human Nectin-like Molecule-1/Syncam3/Tsll1/Igsf4b, a Neural Tissue-specific Immunoglobulin-like Cell-Cell Adhesion Molecule J.Biol.Chem., 281, 2006
1XT5	Crystal Structure of VCBP3, domain 1, from Branchiostoma floridae Descriptor: SULFATE ION, variable region-containing chitin-binding protein 3 Authors: Hernandez Prada, J.A, Haire, R.N, Cannon, J.P, Allaire, M, Jakoncic, J, Stojanoff, V, Litman, G.W, Ostrov, D.A. Deposit date: 2004-10-21 Release date: 2005-10-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus. Nat.Immunol., 7, 2006

<12345678910111213141516>