5IR3

Crystal structure of the recombinant highest fibrillogenic natural mutant (obtained from patient AR) derived from lambda 6 light chain variable domain

Summary for 5IR3

Entry DOI	10.2210/pdb5ir3/pdb
Related	2W0K 3B5G 3BDX 5C9K
Descriptor	Ig lambda chain V-VI region AR, ACETATE ION (3 entities in total)
Functional Keywords	beta-sandwich, immunoglobulin, al amyloidosis, immune system
Biological source	Homo sapiens (Human)
Cellular location	Secreted : P01721
Total number of polymer chains	1
Total formula weight	11985.86
Authors	Hernandez-Santoyo, A.,Rodriguez-Romero, A. (deposition date: 2016-03-11, release date: 2017-06-14, Last modification date: 2023-09-27)
Primary citation	Luna-Martinez, O.D.,Hernandez-Santoyo, A.,Villalba-Velazquez, M.I.,Sanchez-Alcala, R.,Fernandez-Velasco, D.A.,Becerril, B. Stabilizing an amyloidogenic lambda 6 light chain variable domain. FEBS J., 284:3702-3717, 2017 Cited by PubMed: 28898537 DOI: 10.1111/febs.14265 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation