5IR3

Crystal structure of the recombinant highest fibrillogenic natural mutant (obtained from patient AR) derived from lambda 6 light chain variable domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0003823	molecular_function	antigen binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 201

Chain	Residue
A	SER32
A	TYR94
A	ASN95
A	HIS98
A	HOH331

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	97
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	24
Details	Region: {"description":"Framework-1","evidences":[{"source":"PubMed","id":"10575277","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Region: {"description":"Complementarity-determining-1","evidences":[{"source":"PubMed","id":"10575277","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	16
Details	Region: {"description":"Framework-2","evidences":[{"source":"PubMed","id":"10575277","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	32
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"Complementarity-determining-2","evidences":[{"source":"PubMed","id":"10575277","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	37
Details	Region: {"description":"Framework-3","evidences":[{"source":"PubMed","id":"10575277","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	6
Details	Region: {"description":"Complementarity-determining-3","evidences":[{"source":"PubMed","id":"10575277","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	14
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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