5GGS

PD-1 in complex with pembrolizumab Fab

Summary for 5GGS

• Entry DOI: 10.2210/pdb5ggs/pdb
• Descriptor: heavy chain, light chain, Programmed cell death protein 1, ... (4 entities in total)
• Functional Keywords: antibody, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: Q15116
• Total number of polymer chains: 6
• Total formula weight: 125778.10

Authors

Heo, Y.S. (deposition date: 2016-06-16, release date: 2016-11-09, Last modification date: 2016-11-16)

• Primary citation: Lee, J.Y.,Lee, H.T.,Shin, W.,Chae, J.,Choi, J.,Kim, S.H.,Lim, H.,Won Heo, T.,Park, K.Y.,Lee, Y.J.,Ryu, S.E.,Son, J.Y.,Lee, J.U.,Heo, Y.S.; Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy; Nat Commun, 7:13354-13354, 2016; PubMed: 27796306; DOI: 10.1038/ncomms13354

Experimental method

X-RAY DIFFRACTION (1.997 Å)