5GGS

PD-1 in complex with pembrolizumab Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
Y	0016020	cellular_component	membrane
Y	0050777	biological_process	negative regulation of immune response
Z	0016020	cellular_component	membrane
Z	0050777	biological_process	negative regulation of immune response

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
A	TYR201-HIS207
B	TYR196-HIS202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	110
Details	Domain: {"description":"Ig-like V-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Region: {"description":"Interaction with CD274/PDCD1L1","evidences":[{"source":"PubMed","id":"26602187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	50
Details	Region: {"description":"Pembrolizumab binding","evidences":[{"source":"PubMed","id":"27325296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27734966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5B8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JXE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WT9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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