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2KS9
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Solution conformation of substance P in water complexed with NK1R
分子名称: Substance P, Substance-P receptor
著者Gayen, A, Mukhopadhyay, C.
登録日2009-12-31
公開日2010-11-03
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
2KSB
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Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R
分子名称: Substance P, Substance-P receptor
著者Gayen, A, Mukhopadhyay, C.
登録日2009-12-31
公開日2010-11-03
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
3RZE
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Structure of the human histamine H1 receptor in complex with doxepin
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (3E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, (3Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, ...
著者Shimamura, T, Han, G.W, Shiroishi, M, Weyand, S, Tsujimoto, H, Winter, G, Katritch, V, Abagyan, R, Cherezov, V, Liu, W, Kobayashi, T, Stevens, R, Iwata, S, GPCR Network (GPCR)
登録日2011-05-11
公開日2011-06-15
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of the human histamine H1 receptor complex with doxepin.
Nature, 475, 2011
2KSA
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Substance P in DMPC/CHAPS isotropic q=0.25 bicelles as a ligand for NK1R
分子名称: Substance P, Substance-P receptor
著者Gayen, A, Mukhopadhyay, C.
登録日2009-12-31
公開日2010-11-03
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
5T04
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STRUCTURE OF CONSTITUTIVELY ACTIVE NEUROTENSIN RECEPTOR
分子名称: 3,3',3''-phosphanetriyltripropanoic acid, ARG-ARG-PRO-TYR-ILE-LEU, DI(HYDROXYETHYL)ETHER, ...
著者Krumm, B, Botos, I, Grisshammer, R.
登録日2016-08-15
公開日2016-12-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure and dynamics of a constitutively active neurotensin receptor.
Sci Rep, 6, 2016
5T1A
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Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one, (3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one, ...
著者Zheng, Y, Qin, L, Ortiz Zacarias, N.V, de Vries, H, Han, G.W, Gustavsson, M, Dabros, M, Zhao, C, Cherney, R.J, Carter, P, Stamos, D, Abagyan, R, Cherezov, V, Stevens, R.C, IJzerman, A.P, Heitman, L.H, Tebben, A, Kufareva, I, Handel, T.M.
登録日2016-08-18
公開日2016-12-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.806 Å)
主引用文献Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.
Nature, 540, 2016
5TGZ
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Crystal Structure of the Human Cannabinoid Receptor CB1
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate, Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, ...
著者Hua, T, Vemuri, K, Pu, M, Qu, L, Han, G.W, Wu, Y, Zhao, S, Shui, W, Li, S, Korde, A, Laprairie, R.B, Stahl, E.L, Ho, J.H, Zvonok, N, Zhou, H, Kufareva, I, Wu, B, Zhao, Q, Hanson, M.A, Bohn, L.M, Makriyannis, A, Stevens, R.C, Liu, Z.J.
登録日2016-09-28
公開日2016-11-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Human Cannabinoid Receptor CB1.
Cell, 167, 2016
1HZX
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CRYSTAL STRUCTURE OF BOVINE RHODOPSIN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
著者Teller, D.C, Okada, T, Behnke, C.A, Palczewski, K, Stenkamp, R.E.
登録日2001-01-26
公開日2001-07-04
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs).
Biochemistry, 40, 2001
4XT3
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Structure of a viral GPCR bound to human chemokine CX3CL1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fractalkine, G-protein coupled receptor homolog US28, ...
著者Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C.
登録日2015-01-22
公開日2015-03-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.801 Å)
主引用文献Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
4XEE
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Structure of active-like neurotensin receptor
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ...
著者Krumm, B.E, White, J.F, Shah, P, Grisshammer, R.
登録日2014-12-23
公開日2015-07-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural prerequisites for G-protein activation by the neurotensin receptor.
Nat Commun, 6, 2015
4XT1
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Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Fractalkine, ...
著者Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C.
登録日2015-01-22
公開日2015-03-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.886 Å)
主引用文献Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
4XNV
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The human P2Y1 receptor in complex with BPTU
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-[2-(2-tert-butylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea, CHOLESTEROL, ...
著者Zhang, D, Gao, Z, Jacobson, K, Han, G.W, Stevens, R, Zhao, Q, Wu, B, GPCR Network (GPCR)
登録日2015-01-16
公開日2015-04-01
最終更新日2020-02-05
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
4IAR
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Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target)
分子名称: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine
著者Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR)
登録日2012-12-07
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
4J4Q
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Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside
分子名称: ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ...
著者Park, J.H, Morizumi, T, Li, Y, Hong, J.E, Pai, E.F, Hofmann, K.P, Choe, H.W, Ernst, O.P.
登録日2013-02-07
公開日2013-10-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Opsin, a structural model for olfactory receptors?
Angew.Chem.Int.Ed.Engl., 52, 2013
4X1H
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Opsin/G(alpha) peptide complex stabilized by nonyl-glucoside
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-terminal derived peptide of guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ...
著者Blankenship, E, Lodowski, D.T.
登録日2014-11-24
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation.
Structure, 23, 2015
7P00
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Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex
分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A.
登録日2021-06-29
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (2.71 Å)
主引用文献Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Sci Adv, 7, 2021
7P02
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Human Neurokinin 1 receptor (NK1R) substance P Gs complex
分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A.
登録日2021-06-29
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (2.87 Å)
主引用文献Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features.
Sci Adv, 7, 2021
4XES
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BU of 4xes by Molmil
Structure of active-like neurotensin receptor
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ...
著者Krumm, B.E, White, J.F, Shah, P, Grisshammer, R.
登録日2014-12-24
公開日2015-07-29
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural prerequisites for G-protein activation by the neurotensin receptor.
Nat Commun, 6, 2015
4XNW
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The human P2Y1 receptor in complex with MRS2500
分子名称: P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1, ZINC ION, [(1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate
著者Zhang, D, Gao, Z, Jacobson, K, Han, G.W, Stevens, R, Zhao, Q, Wu, B, GPCR Network (GPCR)
登録日2015-01-16
公開日2015-04-01
最終更新日2020-02-05
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
7PIU
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Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution.
分子名称: CALCIUM ION, Camelid antibody fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P.
登録日2021-08-23
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (2.58 Å)
主引用文献Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
7PIV
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Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution.
分子名称: CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P.
登録日2021-08-23
公開日2021-11-17
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
4IAQ
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Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target)
分子名称: Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine
著者Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR)
登録日2012-12-07
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
4IB4
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Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, ...
著者Wacker, D, Wang, C, Katritch, V, Han, G.W, Huang, X, Vardy, E, McCorvy, J.D, Jiang, Y, Chu, M, Siu, F.Y, Liu, W, Xu, H.E, Cherezov, V, Roth, B.L, Stevens, R.C, GPCR Network (GPCR)
登録日2012-12-07
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural features for functional selectivity at serotonin receptors.
Science, 340, 2013
1JFP
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Structure of bovine rhodopsin (dark adapted)
分子名称: RETINAL, rhodopsin
著者Yeagle, P.L, Choi, G, Albert, A.D.
登録日2001-06-21
公開日2001-10-05
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms.
Biochemistry, 40, 2001
1L9H
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Crystal structure of bovine rhodopsin at 2.6 angstroms RESOLUTION
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HEPTANE-1,2,3-TRIOL, MERCURY (II) ION, ...
著者Okada, T, Fujiyoshi, Y, Silow, M, Navarro, J, Landau, E.M, Shichida, Y.
登録日2002-03-23
公開日2002-05-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 99, 2002

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