2KSB

Substance P in isotropic q=0.25 DMPC/CHAPS/GM1 bicelles as a ligand for NK1R

Summary for 2KSB

DescriptorSubstance-P receptor, Substance P (2 entities in total)
Functional Keywordssubstance p, dmpc/chaps/gm1 bicelle, autodock, nk1r, neuropeptide receptor-neuropeptide complex, neuropeptide receptor/neuropeptide
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane; Multi-pass membrane protein P25103
Secreted P20366
Total number of polymer chains2
Total molecular weight43030.47
Authors
Gayen, A.,Mukhopadhyay, C. (deposition date: 2009-12-31, release date: 2010-11-03, Last modification date: 2011-07-13)
Primary citation
Gayen, A.,Goswami, S.K.,Mukhopadhyay, C.
NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
PubMed: 20937248 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbamem.2010.09.023
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1212.5%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2ksb
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Molmil generated image of 2ksb
rotated about x axis by 90°
Molmil generated image of 2ksb
rotated about y axis by 90°
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