5TGZ

Crystal Structure of the Human Cannabinoid Receptor CB1

Summary for 5TGZ

Entry DOI	10.2210/pdb5tgz/pdb
Descriptor	Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate, FLAVIN MONONUCLEOTIDE, ... (7 entities in total)
Functional Keywords	membrane protein, g protein-coupled receptor, human cannabinoid receptor cb1, marijuana, stabilizing antagonist am6538, lipidic cubic phase, cb1-flavodoxin chimera, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	52646.18
Authors	Hua, T.,Vemuri, K.,Pu, M.,Qu, L.,Han, G.W.,Wu, Y.,Zhao, S.,Shui, W.,Li, S.,Korde, A.,Laprairie, R.B.,Stahl, E.L.,Ho, J.H.,Zvonok, N.,Zhou, H.,Kufareva, I.,Wu, B.,Zhao, Q.,Hanson, M.A.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J. (deposition date: 2016-09-28, release date: 2016-11-02, Last modification date: 2023-11-08)
Primary citation	Hua, T.,Vemuri, K.,Pu, M.,Qu, L.,Han, G.W.,Wu, Y.,Zhao, S.,Shui, W.,Li, S.,Korde, A.,Laprairie, R.B.,Stahl, E.L.,Ho, J.H.,Zvonok, N.,Zhou, H.,Kufareva, I.,Wu, B.,Zhao, Q.,Hanson, M.A.,Bohn, L.M.,Makriyannis, A.,Stevens, R.C.,Liu, Z.J. Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167:750-762.e14, 2016 Cited by PubMed: 27768894 DOI: 10.1016/j.cell.2016.10.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation