5TGZ
Crystal Structure of the Human Cannabinoid Receptor CB1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1 | polymer | 452 | 50337.4 | 1 | UniProt (P21554) UniProt (P00323) Pfam (PF00001) Pfam (PF00258) In PDB | Homo sapiens (Human) | CB1,CANN6,CB1,CANN6 |
2 | A | 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate | non-polymer | 542.4 | 1 | Chemie (ZDG) | |||
3 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
4 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) | |||
5 | A | OLEIC ACID | non-polymer | 282.5 | 3 | Chemie (OLA) | |||
6 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
7 | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A: 99 - 306 (UniProt: P21554)
A: 1002 - 1148 (UniProt: P00323)
A: 332 - 414 (UniProt: P21554)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Ala 210 | Thr 210 | engineered mutation |
Lys 273 | Glu 273 | engineered mutation |
Val 283 | Thr 283 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 1002 | Pro 2 | engineered mutation |
Trp 1098 | Tyr 98 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 340 | Arg 340 | engineered mutation |
His 415 | - | expression tag |
His 416 | - | expression tag |
His 417 | - | expression tag |
His 418 | - | expression tag |
His 419 | - | expression tag |
His 420 | - | expression tag |
His 421 | - | expression tag |
His 422 | - | expression tag |
His 423 | - | expression tag |
His 424 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 50337.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2308.8 | |
All* | Total formula weight | 52646.2 |