5TGZ

Crystal Structure of the Human Cannabinoid Receptor CB1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004949	molecular_function	cannabinoid receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0010181	molecular_function	FMN binding
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue ZDG A 2001

Chain	Residue
A	PHE102
A	LEU359
A	MET363
A	ALA380
A	SER383
A	CYS386
A	LEU387
A	MET103
A	ILE105
A	GLY166
A	PHE170
A	PHE174
A	LEU193
A	VAL196
A	THR197

---

site_id	AC2
Number of Residues	17
Details	binding site for residue FMN A 2002

Chain	Residue
A	SER1010
A	THR1011
A	THR1012
A	GLY1013
A	ASN1014
A	THR1015
A	SER1058
A	THR1059
A	TRP1060
A	GLY1061
A	CYS1093
A	GLY1094
A	ASP1095
A	TRP1098
A	TYR1100
A	PHE1101
A	CYS1102

---

site_id	AC3
Number of Residues	4
Details	binding site for residue OLC A 2003

Chain	Residue
A	ARG226
A	TYR1008
A	GLU1016
A	ASP1037

---

site_id	AC4
Number of Residues	7
Details	binding site for residue OLA A 2004

Chain	Residue
A	PRO151
A	SER152
A	ILE156
A	LEU209
A	ASP213
A	PHE237
A	LEU341

---

site_id	AC5
Number of Residues	1
Details	binding site for residue OLA A 2006

Chain	Residue
A	LEU209

---

Functional Information from PROSITE/UniProt

site_id	PS00201
Number of Residues	17
Details	FLAVODOXIN Flavodoxin signature. IVYgSTtGnTEytAEtI

Chain	Residue	Details
A	ILE1006-ILE1022

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	LEU117-LEU142

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	HIS143-HIS154
A	ASP213-LYS232

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	PHE155-ILE175

---

site_id	SWS_FT_FI4
Number of Residues	39
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	ASP176-ASN187
A	ASN256-LYS273
A	ASP366-THR377

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	VAL188-ILE212

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	ALA233-TRP255

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	THR274-TRP299

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	LEU345-TYR365

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727

Chain	Residue	Details
A	VAL378-LEU399

---