Solution conformation of substance P in water complexed with NK1R

Summary for 2KS9

Related2KSA 2KSB
DescriptorSubstance-P receptor, Substance P (2 entities in total)
Functional Keywordssubstance p, water, autodock, nk1, neuropeptide receptor-neuropeptide complex, neuropeptide receptor/neuropeptide
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Multi-pass membrane protein P25103
Secreted P20366
Total number of polymer chains2
Total molecular weight43030.47
Gayen, A.,Mukhopadhyay, C. (deposition date: 2009-12-31, release date: 2010-11-03, Last modification date: 2011-07-13)
Primary citation
Gayen, A.,Goswami, S.K.,Mukhopadhyay, C.
NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles
Biochim.Biophys.Acta, 2010
PubMed: 20937248 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbamem.2010.09.023
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers1202.5%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation report