2KS9

Solution conformation of substance P in water complexed with NK1R

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004995	molecular_function	tachykinin receptor activity
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
B	0007217	biological_process	tachykinin receptor signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIySMTAVAFDRYMaI

Chain	Residue	Details
A	ALA118-ILE134

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site_id	PS00267
Number of Residues	5
Details	TACHYKININ Tachykinin family signature. FFGLM

Chain	Residue	Details
B	PHE371-MET375

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by FAP => ECO:0000269|PubMed:21314817

Chain	Residue	Details
B	PRO366
A	VAL87-LYS106
A	THR170-LYS194
A	PRO271-ILE283

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by MME => ECO:0000269|PubMed:6208535

Chain	Residue	Details
B	GLN370
B	PHE371

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by ACE => ECO:0000269|PubMed:6208535

Chain	Residue	Details
B	PHE372
A	ASP129-LYS148
A	GLY220-LYS248

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by ACE and MME => ECO:0000269|PubMed:6208535

Chain	Residue	Details
B	GLY373

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Methionine amide => ECO:0000269|PubMed:3770210

Chain	Residue	Details
B	MET375

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site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	VAL149-SER169

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site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
A	VAL195-VAL219

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site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
A	MET249-LEU270

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site_id	SWS_FT_FI9
Number of Residues	24
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
A	GLN284-LEU308

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:8384323

Chain	Residue	Details
A	HIS197

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site_id	SWS_FT_FI11
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000255

Chain	Residue	Details
A	CYS322

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site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN14
A	ASN18

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