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6PLF
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BU of 6plf by Molmil
Crystal structure of human PHGDH complexed with Compound 1
Descriptor: 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase
Authors:Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K.
Deposit date:2019-06-30
Release date:2019-07-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
Bioorg.Med.Chem.Lett., 29, 2019
4E5N
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BU of 4e5n by Molmil
Thermostable phosphite dehydrogenase in complex with NAD
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Thermostable phosphite dehydrogenase
Authors:Zou, Y, Zhang, H, Nair, S.K.
Deposit date:2012-03-14
Release date:2012-05-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration.
Biochemistry, 51, 2012
2DBQ
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BU of 2dbq by Molmil
Crystal Structure of Glyoxylate Reductase (PH0597) from Pyrococcus horikoshii OT3, Complexed with NADP (I41)
Descriptor: GLYCEROL, Glyoxylate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Yoshikawa, S, Arai, R, Kinoshita, Y, Uchikubo-Kamo, T, Akasaka, R, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-16
Release date:2006-06-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate.
Acta Crystallogr.,Sect.D, 63, 2007
2DBZ
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BU of 2dbz by Molmil
Crystal Structure of Glyoxylate Reductase (PH0597) from Pyrococcus horikoshii OT3, Complexed with NADP (P61)
Descriptor: Glyoxylate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
Authors:Yoshikawa, S, Arai, R, Kinoshita, Y, Uchikubo-Kamo, T, Akasaka, R, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-16
Release date:2006-06-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate.
Acta Crystallogr.,Sect.D, 63, 2007
2DBR
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BU of 2dbr by Molmil
Crystal Structure of Glyoxylate Reductase (PH0597) from Pyrococcus horikoshii OT3, Complexed with NADP (P1)
Descriptor: Glyoxylate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
Authors:Yoshikawa, S, Arai, R, Kinoshita, Y, Uchikubo-Kamo, T, Akasaka, R, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-12-16
Release date:2006-06-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate.
Acta Crystallogr.,Sect.D, 63, 2007
4E5M
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BU of 4e5m by Molmil
Thermostable phosphite dehydrogenase E175A/A176R in complex with NADP
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thermostable phosphite dehydrogenase
Authors:Zou, Y, Zhang, H, Nair, S.K.
Deposit date:2012-03-14
Release date:2012-05-30
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration.
Biochemistry, 51, 2012
4DGS
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BU of 4dgs by Molmil
The crystals structure of dehydrogenase from Rhizobium meliloti
Descriptor: Dehydrogenase
Authors:Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, Lafleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2012-01-26
Release date:2012-02-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystals structure of dehydrogenase from Rhizobium meliloti
To be Published
8HPG
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BU of 8hpg by Molmil
Crystal structure of phenylpyruvate reductase from Lactobacillus sp. CGMCC 9967
Descriptor: Phenylpyruvate reductase
Authors:Yang, J.H, Song, W.
Deposit date:2022-12-12
Release date:2023-12-20
Method:X-RAY DIFFRACTION (3.895 Å)
Cite:One-Pot Biocatalytic Transformation of L-DOPA to D-Danshensu
To Be Published
6RJ3
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BU of 6rj3 by Molmil
Crystal structure of PHGDH in complex with compound 15
Descriptor: 4-[(1~{R})-1-[(2-methyl-5-phenyl-pyrazol-3-yl)carbonylamino]ethyl]benzoic acid, D-3-phosphoglycerate dehydrogenase, SULFATE ION
Authors:Bader, G, Wolkerstorfer, B, Zoephel, A.
Deposit date:2019-04-26
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
8HTY
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BU of 8hty by Molmil
Candida boidinii Formate Dehydrogenase Crystal Structure at 1.4 Angstrom Resolution
Descriptor: Formate dehydrogenase, SULFATE ION
Authors:Gul, M, Yuksel, B, Bulut, H, DeMirci, H.
Deposit date:2022-12-22
Release date:2023-01-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural analysis of wild-type and Val120Thr mutant Candida boidinii formate dehydrogenase by X-ray crystallography.
Acta Crystallogr D Struct Biol, 79, 2023
8I5Z
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BU of 8i5z by Molmil
LDH Mutant P101Q-(An unexpected single-point mutation triggers the unleashing of catalytic potential of a NADH-dependent dehydrogenase)
Descriptor: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Authors:Liu, J.Q.
Deposit date:2023-01-26
Release date:2023-09-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase.
Structure, 31, 2023
6RJ6
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BU of 6rj6 by Molmil
Crystal structure of PHGDH in complex with BI-4924
Descriptor: 2-[4-[(1~{S})-1-[[4,5-bis(chloranyl)-1,6-dimethyl-indol-2-yl]carbonylamino]-2-oxidanyl-ethyl]phenyl]sulfonylethanoic acid, D-3-phosphoglycerate dehydrogenase
Authors:Bader, G, Wolkerstorfer, B, Zoephel, A.
Deposit date:2019-04-26
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
2EKL
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BU of 2ekl by Molmil
Structure of ST1218 protein from Sulfolobus tokodaii
Descriptor: D-3-phosphoglycerate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lokanath, N.K, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-23
Release date:2008-03-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structure of ST1218 protein from Sulfolobus tokodaii
To be Published
8IQ7
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BU of 8iq7 by Molmil
Ambient Temperature Crystal Structure of Candida boidinii Formate Dehydrogenase
Descriptor: Formate dehydrogenase
Authors:Gul, M, DeMirci, H.
Deposit date:2023-03-16
Release date:2023-03-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of wild-type and Val120Thr mutant Candida boidinii formate dehydrogenase by X-ray crystallography.
Acta Crystallogr D Struct Biol, 79, 2023
8IVJ
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BU of 8ivj by Molmil
Candida boidinii Formate Dehydrogenase V120T Mutant
Descriptor: Formate dehydrogenase
Authors:Gul, M, Yuksel, B, Bulut, H, DeMirci, H.
Deposit date:2023-03-28
Release date:2023-05-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of wild-type and Val120Thr mutant Candida boidinii formate dehydrogenase by X-ray crystallography.
Acta Crystallogr D Struct Biol, 79, 2023
6RIH
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BU of 6rih by Molmil
Crystal structure of PHGDH in complex with compound 9
Descriptor: D-3-phosphoglycerate dehydrogenase, SULFATE ION, ~{N}-cyclopropyl-2-methyl-5-phenyl-pyrazole-3-carboxamide
Authors:Bader, G, Wolkerstorfer, B, Zoephel, A.
Deposit date:2019-04-24
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
6RJ2
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BU of 6rj2 by Molmil
Crystal structure of PHGDH in complex with compound 40
Descriptor: D-3-phosphoglycerate dehydrogenase, SULFATE ION, ~{N}-[(1~{R})-1-[4-(ethanoylsulfamoyl)phenyl]ethyl]-2-methyl-5-phenyl-pyrazole-3-carboxamide
Authors:Bader, G, Wolkerstorfer, B, Zoephel, A.
Deposit date:2019-04-26
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
8J3O
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BU of 8j3o by Molmil
Formate dehydrogenase wild-type enzyme from Candida dubliniensis complexed with NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Formate dehydrogenase, MAGNESIUM ION
Authors:Ma, W, Zheng, Y.C, Geng, Q, Chen, C.
Deposit date:2023-04-17
Release date:2023-09-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Engineering a Formate Dehydrogenase for NADPH Regeneration.
Chembiochem, 24, 2023
8J3P
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BU of 8j3p by Molmil
Formate dehydrogenase mutant from from Candida dubliniensis M4 complexed with NADP+
Descriptor: Formate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Ma, W, Zheng, Y.C, Geng, Q, Chen, C, Xu, J.H.
Deposit date:2023-04-17
Release date:2023-09-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Engineering a Formate Dehydrogenase for NADPH Regeneration.
Chembiochem, 24, 2023
4G2N
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BU of 4g2n by Molmil
Crystal structure of putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding from Polaromonas sp. JS6 66
Descriptor: CHLORIDE ION, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, ...
Authors:Malashkevich, V.N, Bhosle, R, Toro, R, Hillerich, B, Gizzi, A, Garforth, S, Kar, A, Chan, M.K, Lafluer, J, Patel, H, Matikainen, B, Chamala, S, Lim, S, Celikgil, A, Villegas, G, Evans, B, Zenchek, W, Love, J, Fiser, A, Khafizov, K, Seidel, R, Bonanno, J.B, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2012-07-12
Release date:2012-07-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding from Polaromonas sp. JS6 66
To be Published
6RJ5
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BU of 6rj5 by Molmil
Crystal structure of PHGDH in complex with compound 39
Descriptor: 2-methyl-~{N}-[(1~{R})-1-[4-(methylsulfonylcarbamoyl)phenyl]ethyl]-5-phenyl-pyrazole-3-carboxamide, D-3-phosphoglycerate dehydrogenase, SULFATE ION
Authors:Bader, G, Wolkerstorfer, B, Zoephel, A.
Deposit date:2019-04-26
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
J.Med.Chem., 62, 2019
2DLD
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BU of 2dld by Molmil
D-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-LACTATE DEHYDROGENASE, OXAMIC ACID
Authors:Dunn, C.R, Holbrook, J.J.
Deposit date:1995-10-28
Release date:1996-03-14
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Dehydrogenases Engineering to Correct Substrate Inhibition in a Commercial Dehydrogenase
To be Published
2D0I
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BU of 2d0i by Molmil
Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3
Descriptor: dehydrogenase
Authors:Lokanath, N.K, Terao, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-08-02
Release date:2006-02-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3
To be Published
5N53
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BU of 5n53 by Molmil
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with N-(3-chloro-4-methoxyphenyl) acetamide
Descriptor: D-3-phosphoglycerate dehydrogenase, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide
Authors:Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J.
Deposit date:2017-02-12
Release date:2017-04-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
2HU2
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BU of 2hu2 by Molmil
CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide
Descriptor: 9-mer peptide from Zinc finger protein 217, C-terminal-binding protein 1, FORMIC ACID, ...
Authors:Nardini, M, Bolognesi, M, Quinlan, K.G.R, Verger, A, Francescato, P, Crossley, M.
Deposit date:2006-07-26
Release date:2006-10-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Specific Recognition of ZNF217 and Other Zinc Finger Proteins at a Surface Groove of C-Terminal Binding Proteins
Mol.Cell.Biol., 26, 2006

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PDB entries from 2024-09-18

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