6PLF
Crystal structure of human PHGDH complexed with Compound 1
Summary for 6PLF
Entry DOI | 10.2210/pdb6plf/pdb |
Descriptor | D-3-phosphoglycerate dehydrogenase, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | dehydrogenase, serine metabolism, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68519.59 |
Authors | Olland, A.,Lakshminarasimhan, D.,White, A.,Suto, R.K. (deposition date: 2019-06-30, release date: 2019-07-24, Last modification date: 2024-03-13) |
Primary citation | Mullarky, E.,Xu, J.,Robin, A.D.,Huggins, D.J.,Jennings, A.,Noguchi, N.,Olland, A.,Lakshminarasimhan, D.,Miller, M.,Tomita, D.,Michino, M.,Su, T.,Zhang, G.,Stamford, A.W.,Meinke, P.T.,Kargman, S.,Cantley, L.C. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29:2503-2510, 2019 Cited by PubMed: 31327531DOI: 10.1016/j.bmcl.2019.07.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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