6PLF

Crystal structure of human PHGDH complexed with Compound 1

Summary for 6PLF

• Entry DOI: 10.2210/pdb6plf/pdb
• Descriptor: D-3-phosphoglycerate dehydrogenase, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: dehydrogenase, serine metabolism, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 68519.59

Authors

Olland, A.,Lakshminarasimhan, D.,White, A.,Suto, R.K. (deposition date: 2019-06-30, release date: 2019-07-24, Last modification date: 2024-03-13)

• Primary citation: Mullarky, E.,Xu, J.,Robin, A.D.,Huggins, D.J.,Jennings, A.,Noguchi, N.,Olland, A.,Lakshminarasimhan, D.,Miller, M.,Tomita, D.,Michino, M.,Su, T.,Zhang, G.,Stamford, A.W.,Meinke, P.T.,Kargman, S.,Cantley, L.C.; Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.; Bioorg.Med.Chem.Lett., 29:2503-2510, 2019; PubMed: 31327531; DOI: 10.1016/j.bmcl.2019.07.011

Experimental method

X-RAY DIFFRACTION (1.7 Å)