Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue ONV A 401 |
| Chain | Residue |
| A | TYR174 |
| A | LEU216 |
| A | HOH505 |
| A | HOH529 |
| A | HOH531 |
| A | HOH579 |
| B | GLU194 |
| A | ASP175 |
| A | PRO176 |
| A | ILE178 |
| A | HIS206 |
| A | THR207 |
| A | PRO208 |
| A | SER212 |
| A | THR213 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | GLU242 |
| A | PHE262 |
| A | ASP269 |
| A | ARG270 |
| A | LEU272 |
| A | VAL273 |
| A | HOH509 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | LYS170 |
| A | THR171 |
| A | GLY187 |
| A | GLN189 |
| A | HOH562 |
| A | HOH573 |
| B | ASP130 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LEU117 |
| A | GLN120 |
| A | GLN123 |
| A | ARG230 |
| A | ALA255 |
| A | HOH502 |
| A | HOH533 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue ONV B 401 |
| Chain | Residue |
| A | GLU194 |
| A | HOH529 |
| B | ARG155 |
| B | TYR174 |
| B | ASP175 |
| B | PRO176 |
| B | ILE177 |
| B | ILE178 |
| B | LEU193 |
| B | HIS206 |
| B | THR207 |
| B | PRO208 |
| B | SER212 |
| B | THR213 |
| B | LEU216 |
| B | HOH509 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | GLU242 |
| B | PRO267 |
| B | ASP269 |
| B | ARG270 |
| B | LEU272 |
| B | VAL273 |
| B | HOH599 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | LEU117 |
| B | GLN120 |
| B | GLN123 |
| B | ARG230 |
| B | ALA255 |
| B | ASN277 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGILGlGRIGrevatrmqsfgmk.TIgYD |
| Chain | Residue | Details |
| A | LEU148-ASP175 | |
| site_id | PS00670 |
| Number of Residues | 23 |
| Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. IWplCDFItVHtPllpsTtgLlN |
| Chain | Residue | Details |
| A | ILE196-ASN218 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. CKkGvRVVNcARGgIVD |
| Chain | Residue | Details |
| A | CYS225-ASP241 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | ARG236 | |
| B | ARG236 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU265 | |
| B | GLU265 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor |
| Chain | Residue | Details |
| A | HIS283 | |
| B | HIS283 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|Ref.21 |
| Chain | Residue | Details |
| A | ASP175 | |
| A | THR207 | |
| A | CYS234 | |
| A | ASP260 | |
| A | HIS283 | |
| B | THR78 | |
| B | ARG155 | |
| B | ASP175 | |
| B | THR207 | |
| B | CYS234 | |
| B | ASP260 | |
| B | HIS283 | |
| A | THR78 | |
| A | ARG155 | |
| Chain | Residue | Details |
| A | SER14 | |
| B | SER14 | |
| Chain | Residue | Details |
| A | LYS21 | |
| B | LYS21 | |
| Chain | Residue | Details |
| B | LYS58 | |
| A | LYS58 | |
| Chain | Residue | Details |
| B | THR78 | |
| A | THR78 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| B | LYS21 | |
| A | LYS21 | |
