6PLF
Crystal structure of human PHGDH complexed with Compound 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | D-3-phosphoglycerate dehydrogenase | polymer | 314 | 33630.8 | 2 | UniProt (O43175) Pfam (PF00389) Pfam (PF02826) | Homo sapiens (Human) | 3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase |
| 2 | C, G (A, B) | 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid | non-polymer | 473.9 | 2 | Chemie (ONV) | |||
| 3 | D, E, F, H, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 283 | Chemie (HOH) |
Sequence modifications
A, B: 4 - 315 (UniProt: O43175)
| PDB | External Database | Details |
|---|---|---|
| Ser 2 | - | expression tag |
| Met 3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67261.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1258.1 | |
| All* | Total formula weight | 68519.6 |
