PDB: 293 resultsInfo pagesStatus searchChemie searchBIRD

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8GZG	Cryo-EM structure of Synechocystis sp. PCC 6803 RPitc Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Shen, L.Q, You, L.L, Zhang, Y. Deposit date: 2022-09-27 Release date: 2023-04-19 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Proc.Natl.Acad.Sci.USA, 2023
4OIP	Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... Authors: Zhang, Y, Ebright, R.H, Arnold, E. Deposit date: 2014-01-20 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.4 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
4OIQ	Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... Authors: Zhang, Y, Ebright, R.H, Arnold, E. Deposit date: 2014-01-20 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.624 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
8H3V	Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. Deposit date: 2022-10-09 Release date: 2023-10-04 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
8H40	Cryo-EM structure of the transcription activation complex NtcA-TAC Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. Deposit date: 2022-10-09 Release date: 2023-10-04 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
4JK1	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine tetraphosphate (ppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
8HIH	Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Shi, J, Xu, J.C. Deposit date: 2022-11-20 Release date: 2023-06-07 Last modified: 2024-07-31 Method: ELECTRON MICROSCOPY (3.66 Å) Cite: Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
8IGR	Cryo-EM structure of CII-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
8IGS	Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
4KI2	Crystallographic analysis of an RNA-polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA Descriptor: DNA (5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3'), POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2013-05-01 Release date: 2013-09-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystallographic analysis of an RNA polymerase sigma-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes. Acta Crystallogr.,Sect.F, 69, 2013
4OIN	Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... Authors: Zhang, Y, Ebright, R.H, Arnold, E. Deposit date: 2014-01-20 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
4MEX	Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H. Deposit date: 2013-08-27 Release date: 2014-05-21 Last modified: 2014-06-25 Method: X-RAY DIFFRACTION (3.902 Å) Cite: Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife, 3, 2014
4JKR	Crystal Structure of E. coli RNA Polymerase in complex with ppGpp Descriptor: DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zuo, Y, Wang, Y, Steitz, T.A. Deposit date: 2013-03-11 Release date: 2013-05-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.2 Å) Cite: The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol.Cell, 50, 2013
8HVR	Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wang, Y, Zheng, J. Deposit date: 2022-12-27 Release date: 2023-12-27 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
4JK2	X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine pentaphosphate (pppGpp) Descriptor: Escherichia coli RNA polymerase alpha subunit, Escherichia coli RNA polymerase beta subunit, Escherichia coli RNA polymerase beta' subunit, ... Authors: Murakami, K.S. Deposit date: 2013-03-09 Release date: 2013-04-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (4.201 Å) Cite: Differential regulation by ppGpp versus pppGpp in Escherichia coli. Nucleic Acids Res., 41, 2013
4KMU	X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S. Deposit date: 2013-05-08 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.85 Å) Cite: X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J.Med.Chem., 56, 2013
4OIR	Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ... Authors: Zhang, Y, Ebright, R.H, Arnold, E. Deposit date: 2014-01-20 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.105 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
4MQ9	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 Descriptor: (2Z)-2-methylbut-2-enoic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Ho, M.X, Arnold, E, Ebright, R.H, Zhang, Y, Tuske, S. Deposit date: 2013-09-16 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.35 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
8JKE	AfsR(T337A) transcription activation complex Descriptor: DNA(65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wang, Y, Zheng, J. Deposit date: 2023-06-01 Release date: 2024-02-14 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
4KN4	X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2b Descriptor: Benzoxazinorifamycin-2b, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Murakami, K.S. Deposit date: 2013-05-08 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.965 Å) Cite: X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J.Med.Chem., 56, 2013
4KN7	X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c Descriptor: Benzoxazinorifamycin-2c, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Murakami, K.S. Deposit date: 2013-05-08 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.686 Å) Cite: X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins. J.Med.Chem., 56, 2013
4LK1	Crystal Structure Analysis of the E.coli holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Bae, B, Darst, S.A. Deposit date: 2013-07-05 Release date: 2013-11-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.8369 Å) Cite: Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA, 110, 2013
4OIO	Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... Authors: Zhang, Y, Ebright, R.H, Arnold, E. Deposit date: 2014-01-20 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3, 2014
4Q5S	Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ... Authors: Murakami, K.S. Deposit date: 2014-04-17 Release date: 2014-07-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014
4LLG	Crystal Structure Analysis of the E.coli holoenzyme/Gp2 complex Descriptor: Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Bae, B, Darst, S.A. Deposit date: 2013-07-09 Release date: 2013-11-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.7936 Å) Cite: Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA, 110, 2013

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