4MQ9
Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077
Summary for 4MQ9
Entry DOI | 10.2210/pdb4mq9/pdb |
Related PRD ID | PRD_001181 |
Descriptor | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (10 entities in total) |
Functional Keywords | dna-directed rna polymerase, transcription, transferase-antibiotic complex, transferase/antibiotic |
Biological source | Thermus thermophilus More |
Cellular location | Cytoplasm (By similarity): Q5SKW1 |
Total number of polymer chains | 7 |
Total formula weight | 429585.67 |
Authors | Ho, M.X.,Arnold, E.,Ebright, R.H.,Zhang, Y.,Tuske, S. (deposition date: 2013-09-16, release date: 2014-05-07, Last modification date: 2023-09-20) |
Primary citation | Zhang, Y.,Degen, D.,Ho, M.X.,Sineva, E.,Ebright, K.Y.,Ebright, Y.W.,Mekler, V.,Vahedian-Movahed, H.,Feng, Y.,Yin, R.,Tuske, S.,Irschik, H.,Jansen, R.,Maffioli, S.,Donadio, S.,Arnold, E.,Ebright, R.H. GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife, 3:e02450-e02450, 2014 Cited by PubMed: 24755292PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.35 Å) |
Structure validation
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