X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c

Summary for 4KN7

Related4KMU 4KN4
DescriptorDNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total)
Functional Keywordstranscription, dna, rna, transferase-antibiotic complex, transferase/antibiotic
Biological sourceEscherichia coli
Total number of polymer chains12
Total molecular weight922194.23
Murakami, K.S. (deposition date: 2013-05-08, release date: 2013-05-22, Last modification date: 2013-07-03)
Primary citation
Molodtsov, V.,Nawarathne, I.N.,Scharf, N.T.,Kirchhoff, P.D.,Showalter, H.D.,Garcia, G.A.,Murakami, K.S.
X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem., 56:4758-4763, 2013
PubMed: 23679862 (PDB entries with the same primary citation)
DOI: 10.1021/jm4004889
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.309243.5%4.8%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution