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2QFW	Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with isocitrate Descriptor: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] Authors: Peng, Y.J, Ding, J.P. Deposit date: 2007-06-28 Release date: 2008-07-01 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction Protein Sci., 17, 2008
2QFX	Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADPH, a-ketoglutarate and Ca(2+) Descriptor: 2-OXOGLUTARIC ACID, CALCIUM ION, Isocitrate dehydrogenase [NADP], ... Authors: Peng, Y.J, Ding, J.P. Deposit date: 2007-06-28 Release date: 2008-07-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction Protein Sci., 17, 2008
3DMS	1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei Descriptor: Isocitrate dehydrogenase [NADP] Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2008-07-01 Release date: 2008-07-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase. Biochemistry, 50, 2011
2ZTW	Structure of 3-isopropylmalate dehydrogenase in complex with the inhibitor and NAD+ Descriptor: (2Z)-2-hydroxy-3-(methylsulfanyl)prop-2-enoic acid, 3-isopropylmalate dehydrogenase, MAGNESIUM ION, ... Authors: Nango, E, Kumasaka, T, Eguchi, T. Deposit date: 2008-10-10 Release date: 2009-10-13 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.79 Å) Cite: Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor Bioorg.Med.Chem., 17, 2009
3INM	Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+) Descriptor: 2-OXOGLUTARIC ACID, CALCIUM ION, GLYCEROL, ... Authors: Fontano, E, Brown, R.S, Suto, R.K, Bhyravbhatla, B. Deposit date: 2009-08-12 Release date: 2009-11-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature, 462, 2009
3FLK	Crystal Structure of Tartrate Dehydrogenase from Pseudomonas putida in complex with NADH, oxalate and metal ion Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, AMMONIUM ION, ... Authors: Malik, R, Viola, R.E. Deposit date: 2008-12-18 Release date: 2009-12-22 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions. Acta Crystallogr.,Sect.D, 66, 2010
3FMX	Crystal structure of Tartrate dehydrogenase from Pseudomonas putida complexed with NADH Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, AMMONIUM ION, Tartrate dehydrogenase/decarboxylase Authors: Malik, R, Viola, R.E. Deposit date: 2008-12-22 Release date: 2010-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural Characterization of Tartrate Dehydrogenase: a versatile enzyme catalyzing multiple reactions To be Published
3LCB	The crystal structure of isocitrate dehydrogenase kinase/phosphatase in complex with its substrate, isocitrate dehydrogenase, from Escherichia coli. Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isocitrate dehydrogenase [NADP], ... Authors: Zheng, J, Jia, Z. Deposit date: 2010-01-10 Release date: 2010-04-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase. Nature, 465, 2010
3MAP	Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate Descriptor: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Yang, B, Peng, Y, Ding, J. Deposit date: 2010-03-24 Release date: 2010-11-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20, 2010
3MAR	Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Yang, B, Peng, Y, Ding, J. Deposit date: 2010-03-24 Release date: 2010-11-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.41 Å) Cite: Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20, 2010
3MAS	Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate Descriptor: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Yang, B, Peng, Y, Ding, J. Deposit date: 2010-03-24 Release date: 2010-11-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20, 2010
2Y41	Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with IPM and MN Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE, 3-ISOPROPYLMALIC ACID, MANGANESE (II) ION Authors: Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. Deposit date: 2011-01-04 Release date: 2011-01-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
2Y40	Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with Mn Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE, MANGANESE (II) ION Authors: Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. Deposit date: 2011-01-04 Release date: 2011-01-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
2Y42	Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with NADH and Mn Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE, BICINE, MANGANESE (II) ION, ... Authors: Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. Deposit date: 2011-01-04 Release date: 2011-01-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
2Y3Z	Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - apo enzyme Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-ISOPROPYLMALATE DEHYDROGENASE, GLYCEROL, ... Authors: Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. Deposit date: 2011-01-04 Release date: 2011-01-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
3AH3	Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution Descriptor: 1,2-ETHANEDIOL, Homoisocitrate dehydrogenase, SULFATE ION Authors: Tomita, T, Suzuki, Y, Kuzuyama, T, Nishiyama, M. Deposit date: 2010-04-13 Release date: 2011-02-02 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution Biochem.J., 431, 2010
3R8W	Structure of 3-isopropylmalate dehydrogenase isoform 2 from Arabidopsis thaliana at 2.2 angstrom resolution Descriptor: 3-isopropylmalate dehydrogenase 2, chloroplastic, ACETATE ION Authors: He, Y, Galant, A, Pang, Q, Strul, J.M, Balogun, S, Jez, J.M, Chen, S. Deposit date: 2011-03-24 Release date: 2011-06-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thaliana. J.Biol.Chem., 286, 2011
3ASJ	Crystal structure of homoisocitrate dehydrogenase in complex with a designed inhibitor Descriptor: (2Z)-3-[(carboxymethyl)sulfanyl]-2-hydroxyprop-2-enoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid, ... Authors: Nango, E, Kumasaka, T, Eguchi, T. Deposit date: 2010-12-13 Release date: 2011-09-21 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor J.Biochem., 150, 2011
3TY3	Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe bound to glycyl-glycyl-glycine Descriptor: GLYCEROL, Probable homoisocitrate dehydrogenase, glycylglycylglycine Authors: Bulfer, S.L, Hendershot, J.M, Trievel, R.C. Deposit date: 2011-09-23 Release date: 2011-11-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe. Proteins, 80, 2012
3TY4	Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe Descriptor: GLYCEROL, Probable homoisocitrate dehydrogenase Authors: Bulfer, S.L, Hendershot, J.M, Trievel, R.C. Deposit date: 2011-09-23 Release date: 2011-11-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe. Proteins, 80, 2012
3UDO	Crystal structure of putative isopropylamlate dehydrogenase from Campylobacter jejuni Descriptor: 1,2-ETHANEDIOL, 3-isopropylmalate dehydrogenase, SULFATE ION Authors: Tkaczuk, K.L, Chruszcz, M, Blus, B.J, Onopriyenko, O, Grimshaw, S, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2011-10-28 Release date: 2011-11-09 Last modified: 2022-04-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of putative isopropylamlate dehydrogenase from Campylobacter jejuni To be Published
3UDU	Crystal structure of putative 3-isopropylmalate dehydrogenase from Campylobacter jejuni Descriptor: 1,2-ETHANEDIOL, 3-isopropylmalate dehydrogenase, CHLORIDE ION Authors: Tkaczuk, K.L, Chruszcz, M, Grimshaw, S, Onopriyenko, O, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2011-10-28 Release date: 2011-11-09 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of putative 3-isopropylmalate dehydrogenase from Campylobacter jejuni To be Published
3US8	Crystal Structure of an isocitrate dehydrogenase from Sinorhizobium meliloti 1021 Descriptor: Isocitrate dehydrogenase [NADP], SULFATE ION Authors: Kumaran, D, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) Deposit date: 2011-11-23 Release date: 2011-12-14 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Crystal Structure of an isocitrate dehydrogenase from Sinorhizobium meliloti 1021 To be Published
3VMJ	3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 Descriptor: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CHLORIDE ION, ... Authors: Nagae, T, Watanabe, N. Deposit date: 2011-12-13 Release date: 2012-02-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1 Acta Crystallogr.,Sect.F, 68, 2012
3VL6	3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 at 580 MPa Descriptor: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CALCIUM ION, ... Authors: Nagae, T, Watanabe, N. Deposit date: 2011-11-29 Release date: 2012-02-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.07 Å) Cite: High-pressure-induced water penetration into 3-isopropylmalate dehydrogenase Acta Crystallogr.,Sect.D, 68, 2012

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