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2QFW
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BU of 2qfw by Molmil
Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with isocitrate
Descriptor: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP]
Authors:Peng, Y.J, Ding, J.P.
Deposit date:2007-06-28
Release date:2008-07-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction
Protein Sci., 17, 2008
2QFX
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BU of 2qfx by Molmil
Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADPH, a-ketoglutarate and Ca(2+)
Descriptor: 2-OXOGLUTARIC ACID, CALCIUM ION, Isocitrate dehydrogenase [NADP], ...
Authors:Peng, Y.J, Ding, J.P.
Deposit date:2007-06-28
Release date:2008-07-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction
Protein Sci., 17, 2008
3DMS
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BU of 3dms by Molmil
1.65A crystal structure of isocitrate dehydrogenase from Burkholderia pseudomallei
Descriptor: Isocitrate dehydrogenase [NADP]
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2008-07-01
Release date:2008-07-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.
Biochemistry, 50, 2011
2ZTW
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BU of 2ztw by Molmil
Structure of 3-isopropylmalate dehydrogenase in complex with the inhibitor and NAD+
Descriptor: (2Z)-2-hydroxy-3-(methylsulfanyl)prop-2-enoic acid, 3-isopropylmalate dehydrogenase, MAGNESIUM ION, ...
Authors:Nango, E, Kumasaka, T, Eguchi, T.
Deposit date:2008-10-10
Release date:2009-10-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor
Bioorg.Med.Chem., 17, 2009
3INM
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BU of 3inm by Molmil
Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)
Descriptor: 2-OXOGLUTARIC ACID, CALCIUM ION, GLYCEROL, ...
Authors:Fontano, E, Brown, R.S, Suto, R.K, Bhyravbhatla, B.
Deposit date:2009-08-12
Release date:2009-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
Nature, 462, 2009
3FLK
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BU of 3flk by Molmil
Crystal Structure of Tartrate Dehydrogenase from Pseudomonas putida in complex with NADH, oxalate and metal ion
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, AMMONIUM ION, ...
Authors:Malik, R, Viola, R.E.
Deposit date:2008-12-18
Release date:2009-12-22
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions.
Acta Crystallogr.,Sect.D, 66, 2010
3FMX
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BU of 3fmx by Molmil
Crystal structure of Tartrate dehydrogenase from Pseudomonas putida complexed with NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, AMMONIUM ION, Tartrate dehydrogenase/decarboxylase
Authors:Malik, R, Viola, R.E.
Deposit date:2008-12-22
Release date:2010-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Characterization of Tartrate Dehydrogenase: a versatile enzyme catalyzing multiple reactions
To be Published
3LCB
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BU of 3lcb by Molmil
The crystal structure of isocitrate dehydrogenase kinase/phosphatase in complex with its substrate, isocitrate dehydrogenase, from Escherichia coli.
Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isocitrate dehydrogenase [NADP], ...
Authors:Zheng, J, Jia, Z.
Deposit date:2010-01-10
Release date:2010-04-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.
Nature, 465, 2010
3MAP
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BU of 3map by Molmil
Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate
Descriptor: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Yang, B, Peng, Y, Ding, J.
Deposit date:2010-03-24
Release date:2010-11-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Cell Res., 20, 2010
3MAR
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BU of 3mar by Molmil
Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP
Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Yang, B, Peng, Y, Ding, J.
Deposit date:2010-03-24
Release date:2010-11-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Cell Res., 20, 2010
3MAS
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BU of 3mas by Molmil
Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate
Descriptor: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Yang, B, Peng, Y, Ding, J.
Deposit date:2010-03-24
Release date:2010-11-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Cell Res., 20, 2010
2Y41
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BU of 2y41 by Molmil
Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with IPM and MN
Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE, 3-ISOPROPYLMALIC ACID, MANGANESE (II) ION
Authors:Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M.
Deposit date:2011-01-04
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase.
Mol.Biosyst., 7, 2011
2Y40
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BU of 2y40 by Molmil
Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with Mn
Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE, MANGANESE (II) ION
Authors:Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M.
Deposit date:2011-01-04
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase.
Mol.Biosyst., 7, 2011
2Y42
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BU of 2y42 by Molmil
Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with NADH and Mn
Descriptor: 3-ISOPROPYLMALATE DEHYDROGENASE, BICINE, MANGANESE (II) ION, ...
Authors:Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M.
Deposit date:2011-01-04
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase.
Mol.Biosyst., 7, 2011
2Y3Z
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BU of 2y3z by Molmil
Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - apo enzyme
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-ISOPROPYLMALATE DEHYDROGENASE, GLYCEROL, ...
Authors:Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M.
Deposit date:2011-01-04
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase.
Mol.Biosyst., 7, 2011
3AH3
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BU of 3ah3 by Molmil
Crystal structure of LR5-1, 3-isopropylmalate dehydrogenase created by directed evolution
Descriptor: 1,2-ETHANEDIOL, Homoisocitrate dehydrogenase, SULFATE ION
Authors:Tomita, T, Suzuki, Y, Kuzuyama, T, Nishiyama, M.
Deposit date:2010-04-13
Release date:2011-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution
Biochem.J., 431, 2010
3R8W
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BU of 3r8w by Molmil
Structure of 3-isopropylmalate dehydrogenase isoform 2 from Arabidopsis thaliana at 2.2 angstrom resolution
Descriptor: 3-isopropylmalate dehydrogenase 2, chloroplastic, ACETATE ION
Authors:He, Y, Galant, A, Pang, Q, Strul, J.M, Balogun, S, Jez, J.M, Chen, S.
Deposit date:2011-03-24
Release date:2011-06-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thaliana.
J.Biol.Chem., 286, 2011
3ASJ
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BU of 3asj by Molmil
Crystal structure of homoisocitrate dehydrogenase in complex with a designed inhibitor
Descriptor: (2Z)-3-[(carboxymethyl)sulfanyl]-2-hydroxyprop-2-enoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, 3-[(carboxymethyl)sulfanyl]-2-oxopropanoic acid, ...
Authors:Nango, E, Kumasaka, T, Eguchi, T.
Deposit date:2010-12-13
Release date:2011-09-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor
J.Biochem., 150, 2011
3TY3
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BU of 3ty3 by Molmil
Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe bound to glycyl-glycyl-glycine
Descriptor: GLYCEROL, Probable homoisocitrate dehydrogenase, glycylglycylglycine
Authors:Bulfer, S.L, Hendershot, J.M, Trievel, R.C.
Deposit date:2011-09-23
Release date:2011-11-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.
Proteins, 80, 2012
3TY4
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BU of 3ty4 by Molmil
Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe
Descriptor: GLYCEROL, Probable homoisocitrate dehydrogenase
Authors:Bulfer, S.L, Hendershot, J.M, Trievel, R.C.
Deposit date:2011-09-23
Release date:2011-11-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.
Proteins, 80, 2012
3UDO
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BU of 3udo by Molmil
Crystal structure of putative isopropylamlate dehydrogenase from Campylobacter jejuni
Descriptor: 1,2-ETHANEDIOL, 3-isopropylmalate dehydrogenase, SULFATE ION
Authors:Tkaczuk, K.L, Chruszcz, M, Blus, B.J, Onopriyenko, O, Grimshaw, S, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-10-28
Release date:2011-11-09
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of putative isopropylamlate dehydrogenase from Campylobacter jejuni
To be Published
3UDU
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BU of 3udu by Molmil
Crystal structure of putative 3-isopropylmalate dehydrogenase from Campylobacter jejuni
Descriptor: 1,2-ETHANEDIOL, 3-isopropylmalate dehydrogenase, CHLORIDE ION
Authors:Tkaczuk, K.L, Chruszcz, M, Grimshaw, S, Onopriyenko, O, Savchenko, A, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-10-28
Release date:2011-11-09
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of putative 3-isopropylmalate dehydrogenase from Campylobacter jejuni
To be Published
3US8
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BU of 3us8 by Molmil
Crystal Structure of an isocitrate dehydrogenase from Sinorhizobium meliloti 1021
Descriptor: Isocitrate dehydrogenase [NADP], SULFATE ION
Authors:Kumaran, D, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2011-11-23
Release date:2011-12-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of an isocitrate dehydrogenase from Sinorhizobium meliloti 1021
To be Published
3VMJ
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BU of 3vmj by Molmil
3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1
Descriptor: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CHLORIDE ION, ...
Authors:Nagae, T, Watanabe, N.
Deposit date:2011-12-13
Release date:2012-02-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1
Acta Crystallogr.,Sect.F, 68, 2012
3VL6
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3-isopropylmalate dehydrogenase from Shewanella oneidensis MR-1 at 580 MPa
Descriptor: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CALCIUM ION, ...
Authors:Nagae, T, Watanabe, N.
Deposit date:2011-11-29
Release date:2012-02-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:High-pressure-induced water penetration into 3-isopropylmalate dehydrogenase
Acta Crystallogr.,Sect.D, 68, 2012

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