3MAS
Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate
Summary for 3MAS
Entry DOI | 10.2210/pdb3mas/pdb |
Related | 3MAP 3MAR |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ... (4 entities in total) |
Functional Keywords | isocitrate dehydrogenase, nicotinamide adenine dinucleotide phosphate, rossmann fold, oxidoreductase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm : O75874 O75874 |
Total number of polymer chains | 2 |
Total formula weight | 96881.13 |
Authors | |
Primary citation | Yang, B.,Zhong, C.,Peng, Y.,Lai, Z.,Ding, J. Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H. Cell Res., 20:1188-1200, 2010 Cited by PubMed: 20975740DOI: 10.1038/cr.2010.145 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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