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3MAS

Crystal structure of heterodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate

Summary for 3MAS
Entry DOI10.2210/pdb3mas/pdb
Related3MAP 3MAR
DescriptorIsocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ... (4 entities in total)
Functional Keywordsisocitrate dehydrogenase, nicotinamide adenine dinucleotide phosphate, rossmann fold, oxidoreductase
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm : O75874 O75874
Total number of polymer chains2
Total formula weight96881.13
Authors
Yang, B.,Peng, Y.,Ding, J. (deposition date: 2010-03-24, release date: 2010-11-10, Last modification date: 2023-11-01)
Primary citationYang, B.,Zhong, C.,Peng, Y.,Lai, Z.,Ding, J.
Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
Cell Res., 20:1188-1200, 2010
Cited by
PubMed: 20975740
DOI: 10.1038/cr.2010.145
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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